Functional Organization of Hypophysiotropic TRH Neurons

促生理垂体 TRH 神经元的功能组织

• 批准号: 9514835
• 负责人: Robert Zoeller
• 金额: $ 9.5万
• 依托单位: University of Massachusetts Amherst
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-06-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9514835&HistoricalAwards=false
• 关键词: Functional; Organization; Hypophysiotropic; TRH; Neurons

Zoeller 9514835 The ability of organisms to respond to cold environments and to nurse their young, in spite of the seemingly disparate nature of these stimuli, actually depends on the activation of the same neurochemical-containing cells in the brain. The chemical produced by these brain cells is a small peptide called thyrotropin-releasing hormone (TRH), which controls metabolism by regulating the secretion of thyroid hormones. Dr. Zoeller is assessing the ability of these stimuli to modify the production of TRH in the brain. Additionally, while TRH is involved in the response to these stimuli, it appears that distinct subpopulations of cells, all producing TRH, are responsible for each response. Using molecular tools, identification of these subpopulations is being explored. The mechanisms involved in organismal responses to the environment and the energy demands place upon them, is critical to the survival of all species of animals, as is the ability to care for their young. A greater understanding of brain mechanisms in these areas will foster our ability to facilitate species survival in captivity and in the wild.

佐勒9514835尽管这些刺激的性质看似不同，但生物体对寒冷环境的反应和哺育幼崽的能力，实际上依赖于大脑中同样含有神经化学物质的细胞的激活。这些脑细胞产生的化学物质是一种叫做促甲状腺激素释放激素(TRH)的小肽，它通过调节甲状腺激素的分泌来控制新陈代谢。佐勒博士正在评估这些刺激改变大脑中TRH产生的能力。此外，虽然TRH参与了对这些刺激的反应，但似乎有不同的细胞亚群负责每一种反应，这些细胞都产生TRH。利用分子工具，正在探索对这些亚群的鉴定。生物体对环境的反应和施加在它们身上的能量需求所涉及的机制，对所有动物物种的生存至关重要，照顾它们幼崽的能力也是如此。对这些区域大脑机制的更多了解将培养我们在圈养和野外促进物种生存的能力。