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Biosynthesis of Secondary Metabolites from Blue-Green Algae

蓝绿藻次生代谢产物的生物合成

基本信息

批准号：
9530794
负责人：
Richard Moore
金额：
$ 34.49万
依托单位：
University of Hawaii
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1996
资助国家：
美国
起止时间：
1996-03-01 至 2000-02-29
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9530794&HistoricalAwards=false
关键词：
Biosynthesis Secondary Metabolites Blue Green

项目摘要

The focus of this research is the biosynthetic study of the cyanobacterial toxins anatoxin a-(s)n Anabaena flos-aquae NCR 525-17, microcystin-LR in Microcystis aeruginosa PCC-7820, the cytotoxins cryptophycin-1 in Nostoc sp. GSV 224, cylindrocyclophane D in Cylindrospermum lichenforme ATCC 29204 and fungal alkaloids from the Stigonemataceae. One of the ultimate goals of the project will be to study biosynthetic processes at the enzymatic level. Also several unnatural C-substituted aspartic acids and beta-alanines will be evaluated as substrates for the `aberrant` biosynthesis of cryptophycin analogs. With this renewal award, the Synthetic Organic Program is supporting the research of Drs. Richard E. Moore and Thomas K. Hemscheidt of the Department of Chemistry at the University of Hawaii, Manoa. Drs. Moore and Hemscheidt will focus their work on biosynthetic studies of cyanobacterial toxins produced by blue-green algae. It is important to learn exactly how potent cyanobacterial toxins are produced , since poisonous blooms of blue-green algae in eutrophic freshwater and brackish lakes present serious environmental and health problems , not only to domestic animals and wildlife that live on the surrounding shores, but to human populations that depend on the water for drinking.

本研究的重点是蓝藻毒素anatoxin a-(s)n Anabaena flos-aquae NCR 525-17、铜绿微囊藻PCC-7820中的微囊藻毒素-LR、发菜中的细胞毒素cryptophycin-1的生物合成研究。 GSV 224、Cylindrospermum lichenforme ATCC 29204 中的 cylindrocyclophane D 以及来自 Stigonemataceae 的真菌生物碱。该项目的最终目标之一是研究酶水平的生物合成过程。此外，还将评估几种非天然 C-取代的天冬氨酸和 β-丙氨酸作为隐藻素类似物“异常”生物合成的底物。凭借这一续签奖项，合成有机计划正在支持 Drs. 的研究。夏威夷大学马诺阿分校化学系的 Richard E. Moore 和 Thomas K. Hemscheidt。博士。摩尔和赫姆沙伊特将把他们的工作重点放在蓝绿藻产生的蓝藻毒素的生物合成研究上。准确了解强效蓝藻毒素是如何产生的非常重要，因为富营养化淡水和咸水湖泊中蓝绿藻的有毒繁殖带来了严重的环境和健康问题，不仅对生活在周围海岸的家畜和野生动物，而且对依赖饮用水的人类群体也是如此。