Epidemiological and Biocultural Correlates of Pregnancy- Related Sickness in Rural Bangladesh

该项目调查孟加拉国农村妇女与妊娠相关疾病的流行病学、荷尔蒙、人口学和文化变量。数据是从1993年对孟加拉国708名妇女进行的前瞻性生殖调查中收集的。203名孕妇每周接受两次访谈和收集尿样，以1)检查妊娠相关疾病的患病率、孕妇的年龄模式和妊娠时机：2)确定激素谱(雌激素、孕酮和人类绒毛膜促性腺激素)与妊娠相关疾病的存在/缺失和妊娠时机的关系；3)确定妊娠结局(活产和流产)与妊娠相关疾病的关系，同时控制母亲年龄、激素谱和产次的影响。免疫分析将被用来量化怀孕期间的激素浓度。描述性统计和事件历史分析将用于检查与妊娠相关的疾病和上述变量之间的关系。这项工作将用于评估关于妊娠相关疾病的病因学、生态学和进化论基础的假说。

This project investigates epidemiological, hormonal, demographic, and cultural variables pertaining to pregnancy-related sickness in rural Bangladeshi women. Data were collected from a prospective reproductive survey of 708 women in Bangladesh in 1993. Twice weekly interviews and urine specimens collected across gestation from 203 pregnant women will be used to 1) examine the prevalence, maternal age pattern, and gestational timing of pregnancy-related sickness: 2) determine the relationship between hormone profiles (estrogen, progesterone, and human chorionic gonadotropin) and the presence/absence and gestational timing of pregnancy-related sickness: and 3) determine the relationship of pregnancy outcome (live birth vs. miscarriage) with pregnancy-related sickness, while simultaneously controlling for the effects of maternal age, hormone profiles, and parity. Immunoassays will be used to quantify hormonal concentrations across gestation. Descriptive statistics and event history analysis will be used to examine the relationships among pregnancy-related sickness and the variables discussed above. This work will be used to evaluate hypotheses on the etiologic, ecological and evolutionary bases of pregnancy-related sickness.