Metal ion-mediated electron transfer in supramolecular DNA architectures

超分子 DNA 结构中金属离子介导的电子转移

• 批准号: 101434803
• 负责人: Professor Dr. Hans-Achim Wagenknecht
• 金额: --
• 依托单位: Institut für Organische Chemie (IOC)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2008
• 资助国家: 德国
• 起止时间: 2007-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/101434803?language=en
• 关键词: Metal; ion; mediated; electron; transfer

It is experimentally verified that unmodified DNA is able to transfer electrons efficiently and fast only over very short distances. Goal of this project is the investigation of DNA-based supramolecular architectures for the electron transfer over embedded metal ions as intermediate charge carriers. Photoinduced electron transfer is applied as a tool with high time resolution (laser) and high spatial resolution (covalently attached chromophore). The second project period will be focused on the synthesis and systematic investigation of single electron transfer pathways in correspondingly designed DNA architectures. This includes linear electron transfer over metal ions that have been incorporated in double helical DNA. Secondly, the electron transfer between two DNA double helices will be investigated. This is a ciritical step for the development of electronically interacting DNA networks. Thirdly, experiments using diarylethenes will be performed to elucidate the possibility to switch the electron transfer path. Additional metal ion coordinating structural motives will be synthesized to increase the complexity of metal ion-based DNA architectures. Thereby, the potential of metal ion-mediated DNA architectures as building blocks for molecular electronics will be elucidated.

实验证明，未经修饰的DNA只有在很短的距离内才能高效、快速地传递电子。本项目的目标是研究基于DNA的超分子结构，用于嵌入金属离子作为中间载流子的电子转移。光致电子转移是一种具有高时间分辨率(激光)和高空间分辨率(共价结合的发色团)的工具。第二个项目阶段将集中于相应设计的DNA结构中单电子转移路径的合成和系统研究。这包括在双螺旋DNA中结合的金属离子上的线性电子转移。其次，将研究两个DNA双螺旋之间的电子转移。这是发展电子相互作用的DNA网络的关键一步。第三，将使用二芳基乙烯进行实验，以阐明切换电子转移路径的可能性。为了增加基于金属离子的DNA结构的复杂性，将合成更多的金属离子配位结构基元。因此，金属离子介导的DNA结构作为分子电子学构建块的潜力将被阐明。

项目成果

Synthesis of DNA conjugates with metalated tetracationic porphyrins by postsynthetic cycloadditions.

通过后环加成合成金属化四阳离子卟啉的 DNA 缀合物

• DOI: 10.1021/ol500364j
• 发表时间: 2014
• 期刊: Organic letters
• 影响因子: 5.2
• 作者: C. Wellner;H.-A. Wagenknecht
• 通讯作者: H.-A. Wagenknecht

Mesityl phenanthroline-modified 2'-deoxyuridine for heteroleptic complexes in metal ion-mediated assembly of DNA.

• DOI: 10.1039/c5dt00100e
• 发表时间: 2015-04
• 期刊: Dalton transactions
• 影响因子: 4
• 作者: P. Ensslen;H. Wagenknecht

Fluorescence quenching over short range in a donor-DNA-acceptor system.

供体-DNA-受体系统中短距离荧光猝灭

• DOI: 10.1002/cphc.201200924
• 发表时间: 2013
• 期刊: Chemphyschem : a European journal of chemical physics and physical chemistry
• 作者: T. Ehrenschwender;Y. Liang;A.-N. Unterreiner;H.-A. Wagenknecht;T. J. A. Wolf
• 通讯作者: T. J. A. Wolf