Immunobiology of the Avian B-G Molecules

本研究关注的是位于主要组织相容性复合体中的高度多态性基因B-G家族，该基因可能是脊椎动物免疫防御中特别受特化和进化变化影响的因素之一。仅在少数物种中检测到B-G基因，并在鸡中进行了检测。该基因家族编码具有提示受体/信号功能结构的表面分子。B-G基因在鸡体内的表达表明，这组基因中的一些基因以组织特异性的方式共同表达。这里的实验将着眼于鸡体内B-G分子的表达模式，这些分子在细胞内和细胞外部分的序列差异，以及这些分子增强免疫反应的能力。这些实验将提供关于鸡免疫系统中另一个研究较少的组成部分及其功能的信息。这些实验处理的是一组基因，它们存在于某些物种的主要组织相容性复合体中，在免疫反应中起重要作用。这项工作将在鸡身上进行，并将提供有关其他物种免疫系统的信息。＊＊＊

Abstract 9604589 Miller This research is concerned with the B-G family of highly polymorphic genes which are located in the major histocompatibility complex, and which may represent one of the elements in vertebrate immune defense particularly subject to specialization and evolutionary change. B-G genes have been detected in only a few species, and have been examined in the chicken. This gene family encodes surface molecules that have a structures suggesting a receptor/signaling function. B-G gene expression in the chicken indicates that some of the genes of this group are expressed together in a tissue specific manner. The experiments here will look at the patterns of expression of the B-G molecules in the chicken, the sequence differences in the intracellular and extracellular portions of the molecules, and the ability of these molecules to enhance the immune response. These experiments will provide information about another poorly studied component of the immune system and its function in the chicken. %%% These experiments are dealing with a group of genes which are present within the major histocompatibility complex of some species, and which are important in the immune response. This work will be done in chickens and will provide information about the immune system of other species. ***