Immunobiology of the Avian B-G Molecules

禽类 B-G 分子的免疫生物学

• 批准号: 9604589
• 负责人: Marcia Miller
• 金额: --
• 依托单位: Beckman Research Institute City of Hope
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9604589&HistoricalAwards=false
• 关键词: Immunobiology; Avian; Molecules

Abstract 9604589 Miller This research is concerned with the B-G family of highly polymorphic genes which are located in the major histocompatibility complex, and which may represent one of the elements in vertebrate immune defense particularly subject to specialization and evolutionary change. B-G genes have been detected in only a few species, and have been examined in the chicken. This gene family encodes surface molecules that have a structures suggesting a receptor/signaling function. B-G gene expression in the chicken indicates that some of the genes of this group are expressed together in a tissue specific manner. The experiments here will look at the patterns of expression of the B-G molecules in the chicken, the sequence differences in the intracellular and extracellular portions of the molecules, and the ability of these molecules to enhance the immune response. These experiments will provide information about another poorly studied component of the immune system and its function in the chicken. %%% These experiments are dealing with a group of genes which are present within the major histocompatibility complex of some species, and which are important in the immune response. This work will be done in chickens and will provide information about the immune system of other species. ***

摘要 9604589 Miller 这项研究涉及高度多态性基因的 B-G 家族，这些基因位于主要组织相容性复合体中，可能代表脊椎动物免疫防御的要素之一，特别容易受到专业化和进化变化的影响。 B-G 基因仅在少数物种中检测到，并且已在鸡中进行了检查。该基因家族编码具有表明受体/信号传导功能的结构的表面分子。鸡中的 B-G 基因表达表明该组的一些基因以组织特异性方式一起表达。这里的实验将着眼于鸡体内 B-G 分子的表达模式、分子胞内和胞外部分的序列差异，以及这些分子增强免疫反应的能力。这些实验将提供有关免疫系统的另一个尚未充分研究的组成部分及其在鸡中的功能的信息。 %%% 这些实验涉及一组基因，这些基因存在于某些物种的主要组织相容性复合体中，并且在免疫反应中很重要。这项工作将在鸡身上进行，并将提供有关其他物种免疫系统的信息。 ***