High Resolution SQUID Magnetometer for Imaging Biological Systems

拟议研究的目标是继续开发超高分辨率超导量子干涉器件（SQUID）磁力计（UHRSM），这些磁力计针对100 m尺度下隔离活组织和小型实验动物制剂中的作用电流、回复磁化和磁化率产生的磁场成像进行了优化。这种测量尚未广泛使用，主要是因为现有仪器的局限性和成本。这个项目是专门为解决这些问题而设计的。拟议中的仪器将能够进行测量，这是不可能与任何其他技术，并应导致新的见解细胞生物学，电生理学，植物学，胚胎学，磁感受，免疫诊断学和神经生理学。

The objective of the proposed research is to continue to develop ultra-high resolution, Superconducting Quantum Interference Device (SQUID) magnetometers (UHRSM) that are optimized for the imaging of the magnetic fields produced by action currents, remanent magnetization, and magnetic susceptibility in isolated living tissue and small experimental animal preparations at the scale of 100 m. Such measurements are not yet in wide spread use, primarily because of the limitations and costs of existing instrumentation. This project is designed specifically to address these points. The proposed instruments will be capable of making measurements that are impossible with any other technique, and should lead to new insights into cellular biology, electrophysiology, botany, embryology, magnetoreception, immunodiagnostics, and neurophysiology.