MRI: Development of a Nanoparticle Trap for Student Training and Nano-Spectroscopy
MRI:开发用于学生培训和纳米光谱学的纳米粒子陷阱
基本信息
- 批准号:0619789
- 负责人:
- 金额:$ 54.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-01 至 2011-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Technical AbstractThe exploration of individual and freely suspended small particles in liquids is presently impaired by Brownian motion which makes a prolonged spectroscopic investigation difficult and for sub 100 nm scaled particles impossible. The proposed instrument will address this challenge through the development of a nanoparticle trap that is expected to allow the positioning, alignment and tracking of individual particles with diameters down to 10 nm. The instrument utilizes novel techniques for interferometric confocal particle detection with high sensitivity and bandwidth, and combines this with feedback controlled electrokinetic or mechanical manipulation of liquid flow in a microfluidic device. Spectroscopic characterization of trapped objects will initially be done using CW and time-resolved fluorescence measurements. The proposed instrument development will thereby provide an interdisciplinary team of researchers from Chemistry-, Pharmacology- and Physics Departments with a unique tool for spectroscopic exploration of individual micron or nano-scale objects in liquid environment. It is envisioned that this instrument may also be used as versatile tool for life sciences allowing prolonged investigation and tracking of viruses, bacteria or self-propelled organisms. The project is coupled to an educational component that consists of training of undergraduate and graduate students with the use of basic as well as advanced optical technologies.Lay AbstractAs the exploration of the nano and micro-cosmos pushes towards new frontiers, challenges emerge that can prevent scientific progress in certain areas. One such challenge are the difficulties encountered with the investigation of individual sub-micron sized objects in liquids. This is due to Brownian motion which sends particles on a random path and makes prolonged investigation by spectroscopic or other means difficult if not impossible. The proposed instrument will help overcome such limitations through the development of a particle trap which will allow positioning, alignment and tracking of objects with diameters down to a few nanometers. This instrument is thereby expected to furnish an interdisciplinary team of researchers from Chemistry, Pharmacology and Physics Departments with a unique and versatile tool for spectroscopic investigations under previously inaccessible conditions. Moreover, it is envisioned that such an instrument may be used as a tool for life sciences, opening new horizons by allowing prolonged investigation and tracking of viruses, bacteria or self-propelled organisms. Research programs drawing on the use of this instrument are expected to benefit the discovery and development of more efficient materials for solid state light sources and better opto- or nanoelectronic devices for future electronic applications.
技术摘要:目前,对液体中单个和自由悬浮的小颗粒的探索受到布朗运动的影响,这使得长时间的光谱研究变得困难,对低于100纳米尺度的颗粒的研究变得不可能。提出的仪器将通过开发纳米粒子陷阱来解决这一挑战,该陷阱有望允许定位,对准和跟踪直径低至10纳米的单个粒子。该仪器利用新型干涉共聚焦粒子检测技术,具有高灵敏度和高带宽,并将其与反馈控制的微流体装置中液体流动的电动或机械操作相结合。捕获对象的光谱表征将首先使用连续波和时间分辨荧光测量完成。因此,拟议的仪器开发将为化学、药理学和物理系的跨学科研究团队提供一种独特的工具,用于在液体环境中对单个微米或纳米级物体进行光谱探索。预计该仪器还可作为生命科学的多功能工具,允许对病毒、细菌或自推进生物进行长期调查和跟踪。该项目与教育组成部分相结合,包括培训本科生和研究生使用基本和先进的光学技术。随着对纳米和微观宇宙的探索不断向新的领域推进,一些挑战也出现了,这些挑战可能会阻碍某些领域的科学进步。其中一个挑战是在研究液体中单个亚微米大小的物体时遇到的困难。这是由于布朗运动使粒子沿随机路径运动,使得用光谱学或其他方法进行长期研究变得困难,如果不是不可能的话。该提议的仪器将通过开发粒子陷阱来帮助克服这些限制,该陷阱将允许定位,对准和跟踪直径小到几纳米的物体。因此,该仪器有望为来自化学、药理学和物理系的跨学科研究团队提供一个独特而通用的工具,用于在以前无法达到的条件下进行光谱研究。此外,预计这种仪器可以用作生命科学的工具,通过允许长期调查和跟踪病毒、细菌或自我推进的生物体,开辟新的视野。利用该仪器的研究项目有望有助于发现和开发更高效的固态光源材料,以及用于未来电子应用的更好的光电或纳米电子器件。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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John Wikswo其他文献
John Wikswo的其他文献
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{{ truncateString('John Wikswo', 18)}}的其他基金
MRI: Development of a fully automated, 1,000-MicroChemostat microfluidic system for parallel, independent, long-duration, machine-guided experiments
MRI:开发全自动、1,000-MicroChemostat 微流体系统,用于并行、独立、长时间、机器引导实验
- 批准号:
2117782 - 财政年份:2021
- 资助金额:
$ 54.69万 - 项目类别:
Standard Grant
High Resolution SQUID Magnetometer for Imaging Biological Systems
用于生物成像系统的高分辨率 SQUID 磁力计
- 批准号:
9604948 - 财政年份:1997
- 资助金额:
$ 54.69万 - 项目类别:
Continuing Grant
High Resolution SQUID Magnetometer for Imaging Biological Systems
用于生物成像系统的高分辨率 SQUID 磁力计
- 批准号:
9513725 - 财政年份:1996
- 资助金额:
$ 54.69万 - 项目类别:
Standard Grant
An Advanced Undergraduate Laboratory in Living State Physics
生命状态物理学高级本科实验室
- 批准号:
7814830 - 财政年份:1978
- 资助金额:
$ 54.69万 - 项目类别:
Standard Grant
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