Tissue Engineering A Blood Vessel

组织工程血管

• 批准号: 9614580
• 负责人: Robert Nerem
• 金额: $ 53.3万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9614580&HistoricalAwards=false
• 关键词: Tissue; Engineering; Blood; Vessel

9614580 Nerem This project is to develop a further understanding of the biology of the vascular wall so as to provide guidance for the development of tissue engineered vascular grafts for the bypass and replacement of diseased vessels. This is to be done by reconstituting a blood vessel in culture from vascular cells and extracellular matrix, and then evaluating this reconstituted blood vessel in a laminar pulsatile flow system. A key question to be answered by this project is whether cell-cell interactions, i.e. between the endothelial cell and vascular smooth muscle cell, are required to create a blood vessel with functional integrity, particularly in regard to its endothelium. ***

9614580 Nerem该项目旨在进一步了解血管壁的生物学，以便为开发用于旁路和置换病变血管的组织工程血管移植物提供指导。 这是通过从血管细胞和细胞外基质在培养物中重建血管，然后在层流脉动流系统中评价该重建的血管来完成的。 该项目要回答的一个关键问题是，是否需要细胞-细胞相互作用，即内皮细胞和血管平滑肌细胞之间的相互作用，以创建具有功能完整性的血管，特别是关于其内皮。 ***