The Tandem Aldol-Tishchenko Reaction: New Methodology for Stereoselective Synthesis

串联羟醛-季琴科反应：立体选择性合成的新方法

• 批准号: 9618233
• 负责人: Keith Woerpel
• 金额: $ 23.6万
• 依托单位: University of California-Irvine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9618233&HistoricalAwards=false
• 关键词: Tandem; Aldol; Tishchenko; Reaction; New

The focus of this research is to develop new methods for sterically controlled carbon-carbon bond formation. The use of the reaction of lithium enolates with excess aldehyde to afford anti 1,3-diol derivatives via a sequence of addition followed by an intramolecular Tishchenko-type hydride-transfer reaction will be explored. The scope, mechanism and application of the methodology to organic synthetic problems will be stressed. With this new award, the Synthetic Organic Program is supporting the research of Dr. Keith A. Woerpel, a young investigator in the Department of Chemistry at the University of California, Irvine. Professor Woerpel will focus his work on developing methods for stereocontrolled carbon-carbon bond formation . The methodology, which uses a sequence of addition and reduction reactions, will offer new pathways for the syntheses of biologically active molecules.

这项研究的重点是开发用于处于空间控制的碳碳键形成的新方法。 将探索锂与多余的醛烯醇的反应，通过一系列添加序列进行抗1,3-二醇衍生物，然后探索分子内Tishchenko型氢化物转移反应。 该方法在有机合成问题上的范围，机制和应用将受到强调。有了这个新奖项，合成有机计划正在支持加利福尼亚大学尔湾分校化学系的年轻调查员Keith A. Woerpel博士的研究。 Woerpel教授将把他的工作集中在开发立体控制的碳碳键形成方法上。 使用一系列添加和还原反应的方法，将为生物活性分子的合成提供新的途径。