Quinones, Radicals and Redox-Active Amino Acids, Gordon Research Conference to be held on May 4th-9th at II Ciocco, Pisa, Italy

醌、自由基和氧化还原活性氨基酸，戈登研究会议将于 5 月 4 日至 9 日在意大利比萨 II Ciocco 举行

• 批准号: 9618564
• 负责人: Joanne Stubbe
• 金额: $ 1.6万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9618564&HistoricalAwards=false
• 关键词: Quinones; Radicals; Redox; Active; Amino

9618564 Stubbe A Gordon Research Conference on "Quinones, Radicals and Redox-Active Amino Acids", will be held May 4th to 9th at Il Ciocco, Italy, under the auspices of this support. This will be the fourth international conference on the subject and will emphasize recent advances in the study of radical and quinone derivatives generated during post-translational modification of amino acid residues by several classes of enzymes such as oxidases, dehydrogenases, reductases, oxygenases, pyroxidases and those involved in molecular rearrangements like pyruvate formate lyase and lysine 2,3-aminomutase. These radicals and quinones act as highly reactive cofactors for effecting difficult catalysis such as C-H bond cleavages. The controlled use of radicals in such enzymes contrasts with the uncontrolled production of radicals which damage biological material. The support is to be used to partially cover travel expenses of scientists attending the meeting, with due priority given to young scientists and under-represented groups. *** Uncontrolled radicals produced in a cell elicit damage, but controlled use of radicals by certain enzymes can produce useful molecules. Quinones and radicals produced by several classes of enzymes can act as cofactors in effective cleavage of chemical bonds that are otherwise difficult to break. Studies on these enzymes have attracted attention of increasing number of scientists, and a fourth international conference on this subject will be held May 4th to 9th at Il Ciocco, Pisa, Italy. The conference will organized by Professor Joanne Stubbe, M. I.T.; fifteen speakers from USA will join a forum of others from England, Italy, Japan, Netherland, Sweden, and elsewhere. Young scientists and under-represented groups will be subsidized by this support to participate in this conference, along with scientists from USA and abroad.

9618564 Stubbe A Gordon研究会议“醌类、自由基和氧化还原活性氨基酸”将于5月4日至9日在意大利的Il Ciocco举行。 这将是第四次国际会议上的主题，并将强调在自由基和醌衍生物的研究中产生的翻译后修饰的氨基酸残基的几类酶，如氧化酶，脱氢酶，还原酶，加氧酶，pyroxidases和那些参与分子重排，如丙酮酸甲酸裂解酶和赖氨酸2，3-aminomutase的最新进展。 这些自由基和醌作为高活性辅因子，用于实现困难的催化作用，如C-H键断裂。 在这些酶中自由基的受控使用与破坏生物材料的自由基的不受控产生形成对比。 这笔资助将用于部分支付出席会议的科学家的旅费，并适当优先考虑青年科学家和代表人数不足的群体。 * 细胞中产生的不受控制的自由基会引起损伤，但某些酶对自由基的控制使用可以产生有用的分子。 由几类酶产生的醌和自由基可以作为辅助因子有效地切割难以断裂的化学键。 关于这些酶的研究已经引起越来越多科学家的注意，关于这一主题的第四次国际会议将于5月4日至9日在意大利比萨的Il Ciocco举行。 会议将由Joanne Stubbe教授组织。信息技术;来自美国的15位演讲者将参加一个由来自英国、意大利、日本、瑞典和其他地方的人组成的论坛。 青年科学家和代表性不足的团体将得到资助，沿着来自美国和国外的科学家参加这次会议。