Acquisition of A 500 MHz NMR Console

请国家科学基金会提供资金，以协助购买500兆赫核磁共振(核磁共振)控制台和两个探头。申请的控制台将取代现有的瓦里安VXR-500控制台(制造于1987年)，并将设在最近扩大的化学系仪器设施(DCIF)。增加一个现代化的500 MHz核磁共振控制台是一项重大计划的组成部分，其中包括耗资54万美元的翻修工程，该工程已在麻省理工学院对多用户DCIF进行升级和现代化改造。具有三个射频通道和脉冲场梯度的500兆赫核磁共振仪器所提供的新能力，对该部开展与生物学有关的研究至关重要。将从收购高场核磁共振仪器中受益的项目大致分为以下几类：(1)药物-DNA相互作用的研究；(2)选择性灭活肿瘤细胞的药物的设计；(3)对蛋白质螺旋性基础的化学理解；以及(4)对小蛋白质的核磁共振研究。目前，DCIF中的两台500 MHz核磁共振控制台已有10多年的历史。现代高场核磁共振仪器的缺乏要求部门研究人员需要最先进的核磁共振技术来获得区域设施的时间，并对生产率造成负面影响。该部正在进行的生物学研究将极大地促进一个500 MHz的核磁共振控制台，该控制台具有更高的灵敏度、更好的垫片、数字滤波、脉冲场梯度、选择性激发和三重共振。

Funds are requested from the NSF to assist in the purchase of a 500 MHz nuclear magnetic resonance (NMR) console and two probes. The requested console will replace an existing Varian VXR-500 console (made in 1987) and will be located in the recently expanded Department of Chemistry's Instrumentation Facility (DCIF). The addition of a modern 500 MHz NMR console is an integral part of a major initiative, including a $540,000 renovation, which is already underway to upgrade and modernize the multi-user DCIF at the Massachusetts Institute of Technology. The new capabilities provided by a 500 MHz NMR instrument with three rf channels and pulsed field gradients are vital for the carrying out of biologically-related research in the Department. Projects that will benefit from the acquisition of a high-field NMR instrument fall into the following general categories: (1) investigations of drug-DNA interactions; (2) design of drugs that selectively inactivate tumor cells; (3) development of a chemical understanding of the basis for helicity in proteins; and (4) NMR studies of small proteins. At present, the two 500 MHz NMR consoles in the DCIF are more than 10 years old. The lack of modern, high-field NMR instrumentation requires Departmental researchers with a need for state-of-the-art NMR technology to obtain time at regional facilities and negatively impacts productivity. Biological research being carried out in the Department would be greatly facilitated by a 500 MHz NMR console with increased sensitivity, better shims, digital filtering, pulsed-field gradients, selective excitation, and triple resonance.