SGER: Development of Photocurable Degradable Polymers for Orthopedic Applications

9619331安塞特拟议研究的目的是开发一种新的可降解聚合物，这种聚合物是可光聚合的，并具有肌肉骨骼应用所需的所需机械性能(特别是在样品降解时)。这项工作对于开发新的策略来恢复因创伤而骨折或因疾病或肿瘤形成而手术切除的骨的结构和机械功能具有重要意义。在肌肉骨骼的应用中，非常需要安全、可降解和坚固的聚合物材料。开发一种可光聚合系统可能是有益的，因为许多原因，包括室温下的快速固化速度，聚合的空间控制，以及完全容易成形和植入期间的灵活性。这些优点导致了牙科、眼科和预防粘连方面的进步，但目前还没有设计出矫形系统。光引发技术可以大大简化骨科聚合物植入物的临床应用。例如，在针孔应用中，可以将粘稠的液体单体引入针孔，系统进行原位光聚合，以提供所需尺寸的硬化聚合物。原位聚合不再需要使用刀片、磨光片和加温设备来成形植入物。此外，该方法为复制复杂形状提供了更快、更好的机制，并应改善聚合物植入物与骨的粘附性。在这个国家，骨折是一个主要的健康问题。最近对美国肌肉骨骼状况的研究估计，每年有200多万人骨折，其中超过28万人是髋部骨折。安全、坚固、易于成型和可降解的聚合物的开发将使许多肌肉骨骼应用受益。***

9619331 Anseth The object of the proposed research is to develop a new class of degradable polymers that is photopolymerizable and exhibits the desired mechanical properties (particularly as the sample degrades) necessary for musculoskeletal applications. This work is important in developing new strategies to restore structural and mechanical function to bone that has been fractured by traumatic injury, or surgically removed because of disease or tumor formation. There is a great need for polymeric materials that are safe, degradable and strong for use in musculoskeletal applications. Development of a photopolymerizable system may be beneficial for many reasons including fast curing rates at room temperature, spatial control of the polymerization, and complete ease of fashioning and flexibility during implantation. These benefits have led to advanced in dentistry, opthamology, and adhesion prevention, but currently no orthopedic systems have been designed. Photoinitiation could greatly simplify the clinical application of orthopedic polymer implants. For example, in pin applications a viscous, liquid monomer could be introduced into a pin hole and the system photopolymerized in situ to render a hardened polymer of the required dimensions. In situ polymerization eliminates the need for shaping the implant with blades, buffs, and warming instruments. Additionally, the process provided a faster and better mechanism for replicating complex shapes and should improve adhesion of the polymer implant to the bone. Bone fractures are a major health concern in this country. Recent studies of musculoskeletal conditions in the United States estimate over 2 million fractures annually which more than 280,000 are hip fractures. Numerous musculoskeletal applications would benefit from the development of safe, strong, easily fashioned, and degradable polymers. ***