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Spectroscopic Characterization of Surfactant and Biopolymer Adsorption in Liquid/Liquid Interfaces and Chemically Modified Metal Surfaces

液/液界面和化学改性金属表面中表面活性剂和生物聚合物吸附的光谱表征

基本信息

批准号：
9626607
负责人：
Robert Corn
金额：
$ 46万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
1996
资助国家：
美国
起止时间：
1996-05-01 至 1999-10-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=9626607&HistoricalAwards=false
关键词：
Spectroscopic Characterization Surfactant Biopolymer Adsorption

项目摘要

This research project, supported in the Analytical and Surface Chemistry Program, investigates the design and spectroscopic characterization of monolayers formed by the adsorption of surfactants, polypeptides and oligonucleotides at liquid/liquid interfaces and at chemically modified metal surfaces. During the tenure of this three-year continuing grant, Professor Corn and his students at the University of Wisconsin will utilize molecular second harmonic generation (SHG) to probe spectroscopically the structure of the liquid/liquid interface. This information is useful for developing an understanding of ion transport across biological membranes, for the design of systems for DNA detection and identification, and for the control of biomimetic systems formed from self-assembled monolayers. The tools and information developed in the course of this research have wide application in a number of areas of fundamental analytical technology. Spectroscopic probes of the orientation of molecules adsorbed at the liquid/liquid interface and in organic overlayers on metallic surfaces are being developed in this research program. Non- linear laser spectroscopic probes, and reflection absorption infrared and plasmon resonance spectroscopies are used to investigate the orientation and structure of molecules at these interfaces. Information obtained from these studies will be useful in the development of new analytical methodologies, as well as forming a fundamental base for the exploitation of biological models of information storage and computing.

该研究项目由分析和表面化学项目支持，研究表面活性剂、多肽和寡核苷酸在液/液界面和化学改性金属表面吸附形成的单层的设计和光谱表征。在这三年的持续资助任期内，玉米教授和他的学生在威斯康星州大学将利用分子二次谐波产生（SHG）探测光谱的液体/液体界面的结构。这一信息是有用的，为发展的理解跨生物膜的离子传输，为DNA检测和识别系统的设计，并为自组装单分子膜形成的仿生系统的控制。在这项研究的过程中开发的工具和信息在基础分析技术的许多领域有着广泛的应用。本研究计划正在开发吸附在液/液界面和金属表面有机覆盖层中的分子取向的光谱探针。非线性激光光谱探针、反射吸收红外光谱和等离子体共振光谱被用来研究这些界面上分子的取向和结构。从这些研究中获得的信息将有助于开发新的分析方法，并为开发信息存储和计算的生物模型奠定基础。