Chitosan-Based Affinity Separation Membranes

摘要本项目将重点研究利用壳聚糖制备用于亲和分离的微孔膜。与目前可用的基于尼龙或纤维素的膜相比，所提出的膜具有含有大量亲水性位点（OH, NH2）的优点。初步实验表明对人血清白蛋白有较高的吸附能力，但力学性能较差。本课题旨在通过制备壳聚糖复合膜来改善膜的力学性能，通过分子印迹技术引入金属螯合基团来提高膜的吸附能力，通过控制孔径来提高膜的渗透性，从而开发出可用于生物技术中蛋白质分离的超活性膜。

CTS - 9629458 Eli Ruckenstein SUNY Buffalo Abstract The project will focus on using chitosan to develop microporous membranes for affinity separations. Compared to currently available membranes based on nylon or cellulose, the proposed membranes have the advantage of containing numerous hydrophilic sites (OH, NH2). Preliminary experiments show high adsorption capacities for human serum albumin but poor mechanical properties. The objectives of the project are to improve the mechanical properties by preparing composite membranes based on chitosan, to increase the adsorption capacity by introducing metal-chelating groups via molecular imprinting, and to improve the permeability by controlling pore size The project may lead to the development of superactive membranes useful for protein separations in biotechnology.