课题基金 / 基金详情

Chitosan-Based Affinity Separation Membranes

Chitosan-Based Affinity Separation Membranes
基于壳聚糖的亲和分离膜
批准号:
9629458
负责人:
Eli Ruckenstein
金额:
$3.5万
依托单位:
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-06-15 至 1997-11-30

项目摘要

项目成果

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中文摘要
翻译
摘要本项目将重点研究利用壳聚糖制备用于亲和分离的微孔膜。与目前可用的基于尼龙或纤维素的膜相比,所提出的膜具有含有大量亲水性位点(OH, NH2)的优点。初步实验表明对人血清白蛋白有较高的吸附能力,但力学性能较差。本课题旨在通过制备壳聚糖复合膜来改善膜的力学性能,通过分子印迹技术引入金属螯合基团来提高膜的吸附能力,通过控制孔径来提高膜的渗透性,从而开发出可用于生物技术中蛋白质分离的超活性膜。
英文摘要
CTS - 9629458 Eli Ruckenstein SUNY Buffalo Abstract The project will focus on using chitosan to develop microporous membranes for affinity separations. Compared to currently available membranes based on nylon or cellulose, the proposed membranes have the advantage of containing numerous hydrophilic sites (OH, NH2). Preliminary experiments show high adsorption capacities for human serum albumin but poor mechanical properties. The objectives of the project are to improve the mechanical properties by preparing composite membranes based on chitosan, to increase the adsorption capacity by introducing metal-chelating groups via molecular imprinting, and to improve the permeability by controlling pore size The project may lead to the development of superactive membranes useful for protein separations in biotechnology.
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Macroporous Cellulose Membrane for Affinity Chromatography
  • 批准号:
    0086687
  • 项目类别:
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  • 资助金额:
    $25.0万
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    2001
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Thermally Reversible Covalent Linking of Halide-containing Polymers
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    0086491
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    2000
  • 负责人:
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  • 项目类别:
    Standard Grant
  • 资助金额:
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  • 负责人:
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Amphiphilic Particles
  • 批准号:
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  • 项目类别:
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  • 资助金额:
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  • 财政年份:
    1998
  • 负责人:
    Eli Ruckenstein
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