Chitosan-Based Affinity Separation Membranes

CTS - 9629458 Eli Ruckenstein SUNY布法罗 摘要 该项目将集中于利用壳聚糖开发用于亲和分离的微孔膜。 与目前可用的基于尼龙或纤维素的膜相比，所提出的膜具有包含许多亲水位点（OH、NH 2）的优点。 初步实验表明，对人血清白蛋白的吸附容量高，但机械性能差。 本项目的目标是通过制备以壳聚糖为基础的复合膜来改善其机械性能，通过分子印迹引入金属螯合基团来增加吸附容量，通过控制孔径来提高渗透性 该项目可能导致生物技术中用于蛋白质分离的超活性膜的开发。

CTS - 9629458 Eli Ruckenstein SUNY Buffalo Abstract The project will focus on using chitosan to develop microporous membranes for affinity separations. Compared to currently available membranes based on nylon or cellulose, the proposed membranes have the advantage of containing numerous hydrophilic sites (OH, NH2). Preliminary experiments show high adsorption capacities for human serum albumin but poor mechanical properties. The objectives of the project are to improve the mechanical properties by preparing composite membranes based on chitosan, to increase the adsorption capacity by introducing metal-chelating groups via molecular imprinting, and to improve the permeability by controlling pore size The project may lead to the development of superactive membranes useful for protein separations in biotechnology.