K+ Channels: Biophysical and Molecular Studies

K 通道：生物物理和分子研究

• 批准号: 9630832
• 负责人: Bernardo Rudy
• 金额: $ 28.2万
• 依托单位: New York University Medical Center
• 依托单位国家: 美国
• 项目类别: Continuing grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 1999-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9630832&HistoricalAwards=false
• 关键词: K+; Channels; Biophysical; Molecular; Studies

9630832 Rudy Nerve cells fire electrical signals, whose frequency is the "Morse code" by which information is transmitted throughout the nervous system. Key in determining the firing frequency of neurons are membrane proteins known as potassium channels. Potassium channels are also important in the regulation of the rhythmic contraction of the heart. Research funded by this grant investigates the molecular composition of one type of potassium channel known as A- type, which is particularly important in the modulation of the firing tempo of neurons and heart cells. These A-type potassium channels regulate firing frequency by periodically changing between active and inactive states. Previous work has shown that the periodicity of activation of A-type potassium channels depends on small molecules that interact with the channel. The goal of this project is to isolate and characterize these small components of A-type potassium channels and identify the genes that encode them. Results from research is expected to significantly increase the understanding of the molecular regulation of nervous system function.

小行星9630832 神经细胞发出电信号，其频率是“莫尔斯码”，信息通过该码在整个神经系统中传输。 决定神经元放电频率的关键是被称为钾通道的膜蛋白。 钾通道在调节心脏的节律性收缩中也很重要。 由该基金资助的研究调查了一种被称为A型的钾通道的分子组成，这种通道在调节神经元和心脏细胞的放电克里思中特别重要。 这些A型钾离子通道通过在活跃和不活跃状态之间周期性地改变来调节放电频率。 先前的工作表明，A型钾通道激活的周期性取决于与通道相互作用的小分子。该项目的目标是分离和表征A型钾通道的这些小组分，并鉴定编码它们的基因。 研究结果有望显著增加对神经系统功能分子调控的理解。