Quasi-Equivalence: Motion and Adaptability in Living Molecules Conference being held second week of January 1997 in Tallahassee, Florida

准等效：活分子运动和适应性会议于 1997 年 1 月第二周在佛罗里达州塔拉哈西举行

• 批准号: 9631049
• 负责人: Kenneth Taylor
• 金额: $ 0.8万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-10-01 至 1997-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9631049&HistoricalAwards=false
• 关键词: Quasi; Equivalence; Motion; Adaptability; Living

9631049 Makowski This grant requests funding for a conference to explore the principles underlying our understanding of the structure and activity of macromolecular assemblies. The conference will take place in the second week of January, 1997, in Tallahassee, Florida. There will be two full days of scientific sessions with talks from approximately 25 speakers. We expect an attendance of 100-150 scientists. In 1962, Caspar and Klug introduced the concept of quasi-equivalence to explain the arrangement of proteins on the surface of icosahedral virus particles. The concept has played an important part in shaping our study and understanding of viruses and other macromolecular assemblies for the past 30 years. In those 30 years the amount of information that we have obtained about proteins has exploded, and the original concept, based on electron microscope studies, has been refined to take into account the remarkable results on the structure of crystalline viruses and other protein-protein interactions. Nevertheless, it survives as a philosophical basis for much of how we think about macromolecular assemblies. By organizing this conference, we seek to bring together the individuals who were involved in the development of the concept from its origins, and those who have generated high resolution information about macromolecular assemblies and viruses over the past 30 years. Most of the principal speakers have already agreed t participate in this conference. This may be one of the last chances we have to bring together the originators of the concepts with so many scientists who have contributed to its development. It is an opportunity to summarize the principles underlying our understanding of macromolecular assemblies, and to define the questions we need to continue asking about the movement and adaptability of macromolecules. %%%

9631049 Makowski这笔赠款要求为一次会议提供资金，以探索我们对大分子组装的结构和活性的理解所依据的原则。会议将于1997年1月的第二周在佛罗里达州的塔拉哈西举行。将有两个整整两天的科学会议，约25名演讲者将发表演讲。我们预计将有100-150名科学家出席。1962年，Caspar和Klug引入了准等价的概念来解释蛋白质在二十面体病毒颗粒表面的排列。在过去的30年里，这一概念在塑造我们对病毒和其他大分子组装的研究和理解方面发挥了重要作用。在这30年里，我们获得的关于蛋白质的信息量呈爆炸式增长，最初的概念基于电子显微镜研究，经过改进，考虑到晶体病毒结构和其他蛋白质-蛋白质相互作用的显著结果。尽管如此，它仍然是我们如何看待大分子组装的哲学基础。通过组织这次会议，我们寻求将从概念起源起参与概念开发的个人，以及那些在过去30年中产生了关于大分子组装和病毒的高分辨率信息的个人聚集在一起。大多数主要演讲者已经同意参加这次会议。这可能是我们将这些概念的发明者与这么多为它的发展做出贡献的科学家聚集在一起的最后机会之一。这是一个机会，总结了我们对大分子组装的理解所依据的原则，并定义了我们需要继续询问的关于大分子的运动和适应性的问题。%%%