SBIR Phase I: A Novel Flat Panel Detector for X-Ray Diffraction

SBIR 第一阶段：用于 X 射线衍射的新型平板探测器

• 批准号: 9660842
• 负责人: Michael Squillante
• 金额: $ 7.44万
• 依托单位: Radiation Monitoring Devices Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9660842&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Flat; Panel

*** 9660842 Squillante This Small Business Innovation Research Phase I project will develop a solid state, large area, high resolution imaging detector by combining the semiconductor film (lead iodide, PbI2) technology being developed by the firm with the large format amorphous silicon (a-Si:H) readout technology which has been developed by Xerox Palo Alto Research Center, a collaborator in the research. Argonne National Laboratory will also collaborate in the effort and will be involved in developing low noise electronics for the detector as well as in conducting macromolecular diffraction studies. Macromolecular crystallography is a very important technique for determining structures of complex biological systems such a proteins, nucleic acids, and viruses. Due to such research on atomic level, the understanding of important biological processes such as enzyme catalysis, viral infection, immune response, hereditary information encoding, and photosynthesis has increased considerably. Macromolecular crystallography in a typical laboratory setting is performed using a rotating-anode X-ray source and an imaging X-ray detector to record the diffraction pattern from various biological samples such as proteins and viruses. Important requirements for the X-ray detectors used in such experiments include large area (10 cm x 10 cm), high resolution (100-200 um), wide dynamic range (104), high sensitivity, and low cost. None of the existing detectors satisfy all requirements and have serious limitations in terms of permanence, size, or cost. The goal of the Phase I project is to demonstrate the feasibility of the proposed approach in meeting these requirements. Potential commercial applications of the research include X-ray diffraction, nondestructive testing, mammography, radiology, X-ray astronomy and environmental studies. ***

* 9660842斯奎兰特 该小型企业创新研究第一阶段项目将开发一种固态，大面积，高分辨率成像探测器，通过将该公司正在开发的半导体薄膜（碘化铅，PbI 2）技术与Xerox Palo Alto研究中心开发的大格式非晶硅（a-Si：H）读出技术相结合。 阿贡国家实验室也将参与这项工作，并将参与开发检测器的低噪声电子器件以及进行大分子衍射研究。 大分子晶体学是测定蛋白质、核酸和病毒等复杂生物系统结构的重要技术。由于这种原子水平的研究，对酶催化、病毒感染、免疫反应、遗传信息编码和光合作用等重要生物过程的理解大大增加。在典型的实验室环境中，使用双阳极X射线源和成像X射线检测器进行大分子晶体学，以记录各种生物样品（如蛋白质和病毒）的衍射图案。 在这种实验中使用的X射线探测器的重要要求包括大面积（10 cm x 10 cm）、高分辨率（100-200 um）、宽动态范围（104）、高灵敏度和低成本。 现有的探测器都不能满足所有的要求，并且在持久性、尺寸或成本方面都有严重的限制。 第一阶段项目的目标是证明所提出的方法在满足这些要求方面的可行性。 该研究的潜在商业应用包括X射线衍射、无损检测、乳房X射线照相术、放射学、X射线天文学和环境研究。 ***