SBIR Phase II: Biological Instrumentation and Resources

SBIR 第二阶段：生物仪器和资源

• 批准号: 9801247
• 负责人: Michael Squillante
• 金额: $ 40万
• 依托单位: Radiation Monitoring Devices Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9801247&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Biological; Instrumentation

*** 9801247 Squillante Macromolecular crystallography is a very important technique for determining structures of complex biological systems such as proteins, nucleic acids, and viruses. Due to such research on the atomic level, the understanding of important biological processes such as enzyme catalysis, viral infection, immune response, hereditary information encoding, and photosynthesis has increased considerably. Currently, detectors used in crystallography include films, CCDS, and storage phosphors. All of these detectors have serious drawbacks in terms of convenience, performance, size, stability or cost. Hence there is a real need for better imaging detectors in macromolecular research. In particular, large area detectors, with good sensitivity, high spatial resolution and low cost are needed to facilitate rapid progress in biological crystallography under typical laboratory conditions. To address this situation, we propose to develop a solid state, large area, high resolution imaging detector by combining semiconductor film (lead iodide) technology being developed at RMD with the large format amorphous silicon readout technology which has been developed by our collaborator, Dr. Street, at Xerox PARC. Dr. Westbrook at Argonne National Laboratory will also collaborate in the proposed effort and his group will be involved in developing low noise electronics for the detector as well as in conducting macromolecular diffraction studies. X-Ray Diffraction, Nondestructive Testing, Mammography, Radiology, X-Ray Astronomy, Environmental Studies. ***

*** 9801247 Squillante 高分子晶体学是确定蛋白质、核酸和病毒等复杂生物系统结构的一项非常重要的技术。 由于这种原子水平的研究，人们对酶催化、病毒感染、免疫反应、遗传信息编码和光合作用等重要生物过程的理解有了很大的提高。 目前，晶体学中使用的探测器包括胶片、CCDS 和存储荧光粉。 所有这些探测器在便利性、性能、尺寸、稳定性或成本方面都存在严重缺陷。 因此，大分子研究确实需要更好的成像探测器。 特别是，需要具有良好灵敏度、高空间分辨率和低成本的大面积探测器，以促进典型实验室条件下生物晶体学的快速进展。 为了解决这一问题，我们建议将 RMD 开发的半导体薄膜（碘化铅）技术与我们的合作者施乐帕洛阿尔托研究中心的 Street 博士开发的大幅面非晶硅读出技术相结合，开发一种固态、大面积、高分辨率成像探测器。 阿贡国家实验室的韦斯特布鲁克博士也将参与拟议的工作，他的团队将参与开发探测器的低噪声电子器件以及进行大分子衍射研究。 X 射线衍射、无损检测、乳房 X 线摄影、放射学、X 射线天文学、环境研究。 ***