CAREER: Immobilization of Enzymes for Detoxification of Organic Compounds

9702603洪流这是一个奖项，为研究提供支持，其主要目标是获得比现在更好的理解，如何固定化酶可以最有效地利用在解毒废物，含有有机磷酸盐的污染意义。 研究人员计划筛选一系列具有不同程度表面活化特征的蛋白质固定化支持物，以鉴定具有大容量吸附酶的蛋白质，然后改变酶以获得酶与其支持物之间的最大连接。 该项目的第二个目标是确定酶在暴露于不利环境条件时保持其活性潜力的条件。 该项目的结果有望为利用固定化酶对具有污染意义的物质进行解毒的工程设计提供见解。 该奖项的提案是根据NSF 96-115“教师早期职业发展（CAREER）计划”提交的。“因此，这个奖项也为这位调查员作为教育家的早期发展提供了支持。 她的教育计划包括开发新课程，强调环境工程实践所固有的多学科视角。 她的创新方法也是针对引导学生，实际上，帮助自己教学。 ***

9702603 Torrents This is an award to provide support for research, the primary objective of which is to obtain a better understanding than now exists of how immobilized enzymes can be utilized most efficiently in detoxifying wastes that contain organic phosphates of pollutional significance. The investigator plans on screening a series of protein immobilization supports with differing degrees of surface activation characteristics to identify those with a large capacity for adsorption of the enzymes and then altering the enzyme to obtain maximum linkage between it and its support. A secondary objective of this project is to identify the conditions under which the enzymes can maintain their potential for activity when exposed to adverse environmental conditions. Results of this project are expected to provide insights into the engineering design of processes to detoxify substance of pollutional significance by use of immobilized enzymes. The proposal leading to this award was submitted in response to NSF 96-115, "Faculty Early Career Development (CAREER) Program." As such, this award also provides support for the continuation of this investigator's early development as an educator. Her education plan includes development of new courses that emphasize the multidisciplinary perspectives that are inherent to the practice of environmental engineering. Her innovative approach also is targeted toward leading students to, in effect, assist in teaching themselves. ***