CAREER: Immobilization of Enzymes for Detoxification of Organic Compounds

职业：固定化酶用于有机化合物解毒

• 批准号: 9702603
• 负责人: Alba Torrents
• 金额: $ 27.5万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9702603&HistoricalAwards=false
• 关键词: CAREER; Immobilization; Enzymes; Detoxification; Organic

9702603 Torrents This is an award to provide support for research, the primary objective of which is to obtain a better understanding than now exists of how immobilized enzymes can be utilized most efficiently in detoxifying wastes that contain organic phosphates of pollutional significance. The investigator plans on screening a series of protein immobilization supports with differing degrees of surface activation characteristics to identify those with a large capacity for adsorption of the enzymes and then altering the enzyme to obtain maximum linkage between it and its support. A secondary objective of this project is to identify the conditions under which the enzymes can maintain their potential for activity when exposed to adverse environmental conditions. Results of this project are expected to provide insights into the engineering design of processes to detoxify substance of pollutional significance by use of immobilized enzymes. The proposal leading to this award was submitted in response to NSF 96-115, "Faculty Early Career Development (CAREER) Program." As such, this award also provides support for the continuation of this investigator's early development as an educator. Her education plan includes development of new courses that emphasize the multidisciplinary perspectives that are inherent to the practice of environmental engineering. Her innovative approach also is targeted toward leading students to, in effect, assist in teaching themselves. ***

9702603激流这是一个为研究提供支持的奖项，其主要目标是比目前更好地了解固定化酶如何最有效地利用含有污染意义的有机磷酸盐的废物。研究人员计划筛选一系列具有不同表面活性特征的蛋白质固定化载体，以确定那些对酶有较大吸附能力的载体，然后对酶进行修饰，以获得其与载体之间的最大连接性。该项目的次要目标是确定当酶暴露在不利的环境条件下时，在什么条件下酶可以保持其活性潜力。该项目的结果有望为利用固定化酶来脱除具有污染意义的物质的工艺的工程设计提供启示。获得该奖项的提案是根据NSF 96-115“教师早期职业发展(Career)计划”提交的。因此，这一奖项也为这位研究人员作为教育工作者的早期发展提供了支持。她的教育计划包括开发新课程，强调环境工程实践中固有的多学科观点。她的创新方法也是为了引导学生实际上帮助自己学习。***