Flow Affinity-Biosensor for Taxol and its Active Analogs and Metabolites

紫杉醇及其活性类似物和代谢物的流式亲和生物传感器

• 批准号: 9713511
• 负责人: Ashok Mulchandani
• 金额: $ 29.27万
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2001-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9713511&HistoricalAwards=false
• 关键词: Flow; Affinity; Biosensor; Taxol; its

9713511 Mulchandani This project is to take advantage of the ability of taxol, and its active analogs and metabolites, to bind reversibly to tubulin and promote its polymerization. This capability of taxol is to be used to develop a biosensor for the measurement of the total anti-cancer activity of taxol in different analyte samples. It is to be demonstrated that such a biosensor will be more specific, sensitive, precise, rapid, cheaper, and easier to operate than presently used techniques for measuring taxol. ***

9713511 Mulchandani该项目是利用紫杉醇及其活性类似物和代谢物可逆地结合微管蛋白并促进其聚合的能力。 紫杉醇的这种能力将被用来开发一种生物传感器，用于测量不同分析物样品中紫杉醇的总抗癌活性。 这是证明，这样的生物传感器将是更具体的，敏感的，精确的，快速的，便宜的，更容易操作比目前使用的技术用于测量紫杉醇。 ***