SST: Nanowire Immunosensors Array for Biowarfare Agents

0529330Mulchandani 在这项研究中，研究人员将制造生物受体功能化的导电/共轭聚合物纳米线，这些纳米线可单独寻址并可扩展到生物传感器阵列。初步研究表明，他们的方法可以在各种条件下检测病毒、细菌和毒素。 该技术涉及在两个接触电极之间特定位置的预制通道中对生物分子友好的导电聚合物进行电化学聚合，以合成具有已知特性的纳米线。 该研究将解决生物受体功能化导电聚合物纳米线的灵敏度、动态范围、检测限、选择性和耐久性。 从这些研究中获得的见解可以使基于纳米线的免疫传感器阵列的设计和制造能够用于检测其他生物战制剂。 电沉积技术在室温/常压条件下操作，能够直接沉积嵌入受体/抗体分子的导电聚合物纳米线，并一步保持这些生物分子处于活性状态，这是一个积极的特征。

0529330MulchandaniIn this research the investigators will fabricate bioreceptor-functionalized conductive/conjugated polymer nanowires that are individually addressable and can be scaled to biosensor arrays. In preliminary studies it is demonstrated that their approach can detect viruses, bacteria and toxins under a variety of conditions. The technology involves electrochemical polymeration of biomolecule-friendly conductive polymers in prefabricated channels between two contact electrodes at a specific position to synthesize nanowires of known properties. The research will address sensitivity, dynamic range, detection limit, selectivity and durability of bioreceptor-functionalized conducting polymer nanowires. Insight gained from these studies could enable the design and fabrication of nanowire-based immunosensor arrays for detection of other biowarfare agents. The fact that the technology of electrodeposition operates under room temperature/pressure conditions, and enables direct deposition of conducting polymer nanowire with embedded receptor/antibody molecules and will maintain these biological molecules in an active state in one step is a positive feature.