SST: Nanowire Immunosensors Array for Biowarfare Agents

SST：用于生物战剂的纳米线免疫传感器阵列

• 批准号: 0529330
• 负责人: Ashok Mulchandani
• 金额: --
• 依托单位: University of California-Riverside
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0529330&HistoricalAwards=false
• 关键词: SST; Nanowire; Immunosensors; Array; Biowarfare

0529330MulchandaniIn this research the investigators will fabricate bioreceptor-functionalized conductive/conjugated polymer nanowires that are individually addressable and can be scaled to biosensor arrays. In preliminary studies it is demonstrated that their approach can detect viruses, bacteria and toxins under a variety of conditions. The technology involves electrochemical polymeration of biomolecule-friendly conductive polymers in prefabricated channels between two contact electrodes at a specific position to synthesize nanowires of known properties. The research will address sensitivity, dynamic range, detection limit, selectivity and durability of bioreceptor-functionalized conducting polymer nanowires. Insight gained from these studies could enable the design and fabrication of nanowire-based immunosensor arrays for detection of other biowarfare agents. The fact that the technology of electrodeposition operates under room temperature/pressure conditions, and enables direct deposition of conducting polymer nanowire with embedded receptor/antibody molecules and will maintain these biological molecules in an active state in one step is a positive feature.

在这项研究中，研究人员将制造生物感受器功能化的导电/共轭聚合物纳米线，这些纳米线可单独寻址，并可按比例调整为生物传感器阵列。初步研究表明，他们的方法可以在各种条件下检测病毒、细菌和毒素。该技术包括将生物分子友好的导电聚合物在特定位置的两个接触电极之间的预制通道中进行电化学聚合，以合成具有已知性质的纳米线。这项研究将涉及生物受体功能化导电聚合物纳米线的灵敏度、动态范围、检测极限、选择性和耐用性。从这些研究中获得的见解可以使基于纳米线的免疫传感器阵列的设计和制造成为可能，用于检测其他生物制剂。电沉积技术在室温/压力条件下工作，能够直接沉积嵌入受体/抗体分子的导电聚合物纳米线，并将在一步内保持这些生物分子的活性，这是一个积极的特征。