Interactive Insect Neuroanatomy Databases for the World Wide Web
万维网交互式昆虫神经解剖学数据库
基本信息
- 批准号:9723657
- 负责人:
- 金额:$ 42.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-09-01 至 2002-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project will continue the development of "Flybrain," an interactive database of the central nervous system of Drosophila and describes specific aims for both levels of database construction. At the deep, infrastructural level (level one), the specific aims of the project include increased automation of data integration and transfer; optimization of interactive viewing and virtual dissection programs; creation of programs to display physiological records; and design and implementation of a concept-based search engine. Level two specific aims focus on the addition of a second core Arias of the thoracic and abdominal central nervous system of Drosophila and the implementation of parallel databases, two devoted to the brains of neurobiologically important insect groups, the other focusing on the evolution of arthropod brains. These developments will provide topical and much needed access to detailed graphical data on the organization of brains and nervous systems of the dominant metazoan Phylum, to the benefit of a wide international community of neuroscientists and evolutionary biologists, as well as new tools for database management and manipulation of three-dimensional data. The implementation of professionally managed neuroscience databases on the World Wide Web provides immediate and extremely efficient access to graphic data on the structure and function of central nervous systems that are particularly relevant to modern research. These databases range from interactive atlases of human brains, through databases on the nervous systems of zebra fish, Aplysia, nematodes, and fruit flies (this project). Three mirror sites in the United States, Germany, and Japan have collaborated in the design and implementation of the project which has made unexpectedly rapid progress in the first 16 months of its National Science Foundation funding. Major advances were achieved in the first funding phase at two levels of database development: 1) the design and implementation of a stable framework and robust mechanisms to acquire, organize, manage, search, and mirror large amounts of image data with minimum maintenance and 2) the installation of comprehensive, annotated searchable atlases of wild- type Drosophila brain with links to allied data such as reconstructed single neurons, pathways, and schematics, as well as homologous structures of other insects. New methods have been implemented for retrieving information from a highly linked network of data modules. Novel graphical representations reveal new ways to view and manipulate two- and three-dimensional structure.
该项目将继续开发“Flybrain”,这是一个关于果蝇中枢神经系统的交互式数据库,并说明了两个层次数据库建设的具体目标。在深层基础设施一级(第一级),该项目的具体目标包括提高数据整合和传输的自动化程度;优化交互式观察和虚拟解剖程序;创建显示生理记录的程序;设计和实施基于概念的搜索引擎。第二级的具体目标集中在增加果蝇的胸部和腹部中枢神经系统的第二个核心阿里亚斯和并行数据库的实施,两个致力于神经生物学重要昆虫群体的大脑,另一个集中在节肢动物大脑的进化。这些发展将提供局部和急需的访问详细的图形数据的组织的大脑和神经系统的占主导地位的后生动物门,有利于广泛的国际社会的神经科学家和进化生物学家,以及新的工具,数据库管理和三维数据的操作。 在万维网上实施专业管理的神经科学数据库,提供了对与现代研究特别相关的中枢神经系统结构和功能的图形数据的即时和极其有效的访问。这些数据库的范围从人脑的交互式地图集,到斑马鱼,Aaplasia,线虫和果蝇的神经系统数据库(本项目)。美国、德国和日本的三个镜像站点在该项目的设计和实施方面进行了合作,该项目在国家科学基金会资助的前16个月取得了意想不到的快速进展。 在第一个供资阶段,在数据库开发的两个层面上取得了重大进展:1)设计和实现稳定的框架和健壮的机制,以最少的维护来获取、组织、管理、搜索和镜像大量图像数据,以及2)安装全面的,野生型果蝇脑的注释可搜索地图集,与相关数据的链接,如重建的单个神经元、通路和示意图,以及其他昆虫的同源结构。已采用新的方法从高度链接的数据模块网络中检索信息。 新颖的图形表示揭示了查看和操纵二维和三维结构的新方法。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Nicholas Strausfeld其他文献
Brain Structure Resolves the Segmental Affinity of Anomalocaridid Appendages
- DOI:
doi:10.1038/nature13486 - 发表时间:
2014 - 期刊:
- 影响因子:
- 作者:
Peiyun cong;Xiaoya Ma;Xianguang Hou;Gregory Edgecombe;Nicholas Strausfeld - 通讯作者:
Nicholas Strausfeld
Nicholas Strausfeld的其他文献
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{{ truncateString('Nicholas Strausfeld', 18)}}的其他基金
Collaborative Research: Origin and Evolutionary Divergence of the Pancrustacean Brain
合作研究:泛甲壳动物大脑的起源和进化分歧
- 批准号:
1754798 - 财政年份:2018
- 资助金额:
$ 42.42万 - 项目类别:
Continuing Grant
2005 Neuroethology Gordon Research Conferences
2005 年神经行为学戈登研究会议
- 批准号:
0451541 - 财政年份:2005
- 资助金额:
$ 42.42万 - 项目类别:
Standard Grant
SGER: Using Split-Brains to Determine the Role of the Mushroom Body Lobes in Learning and Memory
SGER:利用裂脑确定蘑菇体叶在学习和记忆中的作用
- 批准号:
0411958 - 财政年份:2004
- 资助金额:
$ 42.42万 - 项目类别:
Standard Grant
Structure and Function of the Insect Mushroom Body in Sensory and Motor Integration
昆虫蘑菇体在感觉和运动整合中的结构和功能
- 批准号:
9726957 - 财政年份:1998
- 资助金额:
$ 42.42万 - 项目类别:
Continuing Grant
"FLYBRAIN," The First in a Federation of Databases for Insect Neurobiology
“FLYBRAIN”,昆虫神经生物学数据库联盟中的第一个
- 批准号:
9507217 - 财政年份:1995
- 资助金额:
$ 42.42万 - 项目类别:
Continuing Grant
SGER: Neural Systems and Neurogenetic Analysis of Memory Centers
SGER:记忆中心的神经系统和神经遗传学分析
- 批准号:
9316729 - 财政年份:1993
- 资助金额:
$ 42.42万 - 项目类别:
Standard Grant
Synaptic Organization in a Simple Olfactory System
简单嗅觉系统中的突触组织
- 批准号:
9011012 - 财政年份:1991
- 资助金额:
$ 42.42万 - 项目类别:
Continuing Grant
Acquisition of a Computer-Based System for Research on Neuronal Processes
获取用于神经元过程研究的计算机系统
- 批准号:
8716063 - 财政年份:1988
- 资助金额:
$ 42.42万 - 项目类别:
Standard Grant
Neural Circuitry for Polarized-Light Perception
偏振光感知的神经电路
- 批准号:
8719315 - 财政年份:1988
- 资助金额:
$ 42.42万 - 项目类别:
Continuing Grant
相似国自然基金
Insect Science
- 批准号:30824805
- 批准年份:2008
- 资助金额:20.0 万元
- 项目类别:专项基金项目
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