Expanded Porphyrins and Calixpyrroles

扩展卟啉和杯吡咯

• 批准号: 9725399
• 负责人: Jonathan Sessler
• 金额: $ 47.5万
• 依托单位: University of Texas at Austin
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9725399&HistoricalAwards=false
• 关键词: Expanded; Porphyrins; Calixpyrroles

Professor Jonathon L. Sessler, of the Department of Chemistry and Biochemistry at the University of Texas at Austin, is supported by the Organic and Macromolecular Chemistry Program for his studies of expanded porphyrins and calixpyrroles. Through the synthesis of expanded porphyrin systems, including those designed to provide three-dimensional coordination geometries to complement the planar to near-planar geometry afforded by simpler porphyrin derivatives, Professor Sessler assesses the geometric requirements of anion complexation, cation coordination, and neutral substrate binding by these systems. Related studies address the basic molecular recognition properties of two new substrate binding platforms, the calix(n(pyrroles and calix(n)pyridines. The specific interaction between ions or molecules and receptors for them represents a critical feature in countless biochemical processes. Whereas the `molecular recognition` of positively charged species (cations) has received intense scrutiny, the recognition of negatively charged molecules (anions) has developed more slowly. With the support of the Organic and Macromolecular Chemistry Program, Professor Jonathon L. Sessler, of the Department of Chemistry and Biochemistry at the University of Texas at Austin, prepares large-ring cyclic compounds designed to display specific interactions with various anions. Given their unique structural features, many of these compounds also act as binding agents for cations and neutral molecules. Through the synthesis and study of these compounds, Professor Sessler gains critical information regarding the relationship between structure and function in the binding of ions and molecules.

乔纳森·L教授化学系的Sessler和 德克萨斯大学奥斯汀分校的生物化学，由 有机和高分子化学计划，他的研究扩大 卟啉和杯吡咯。 通过合成扩展的 卟啉体系，包括那些设计用于提供三维 协调几何形状，以补充平面到近平面几何形状 由更简单的卟啉衍生物提供，Sessler教授评估了 阴离子络合、阳离子配位和 中性底物通过这些系统结合。 相关研究探讨了 两种新底物结合的基本分子识别性质 平台、杯（n）吡咯和杯（n）吡啶。 离子或分子与它们的受体之间的特殊相互作用 代表了无数生化过程中的一个关键特征。 而带正电荷的物质的“分子识别” （阳离子）受到了严格的审查， 带电荷的分子（阴离子）发展得更慢。 与支撑 有机和高分子化学项目的负责人， L. Sessler说， 德克萨斯大学奥斯汀分校，制备大环环状化合物 设计用来显示与各种阴离子的特定相互作用。 给定 它们独特的结构特征，这些化合物中的许多也作为 阳离子和中性分子的结合剂。 通过合成 通过对这些化合物的研究，塞斯勒教授获得了 关于结构和功能之间关系的信息， 离子和分子的结合。