Expanded Porphyrins and Other Synthetic Polypyrrole Macrocycles

该项目将继续致力于推进扩展的卟啉和相关大环的化学研究。虽然对其天然类似物(例如，卟啉)的研究远远不够，但近年来，扩展的卟啉的化学已经蓬勃发展，部分原因是人们认识到，这类系统在探索芳香性效应、生成新的阳离子络合剂和阴离子识别方面发挥了作用。在即将到来的供资期间，重点将放在通过有理方法和组合方法合成新体系、使用低聚吡咯大环作为生成新的有机金属和配位络合物的框架以及创建聚合物阵列。还将探索所得到的材料在分子识别中的应用。通过这个奖项，有机和高分子化学项目支持德克萨斯大学奥斯汀分校化学系乔纳森·L·塞斯勒教授的研究。塞斯勒教授致力于开发和研究用于医学、超分子化学、配位化学、废物修复和重元素研究的新型吡咯大环。目前制定的项目将提供新的化合物和方法，有助于推动各种后续应用--与药物开发、非线性光学、材料研究、废物补救和全球可持续性相关的研究。

This project will continue work devoted to advancing the chemistry of expanded porphyrins and related macrocycles. While far less well studied than their naturally occurring analogues (e.g., porphyrins), the chemistry of expanded porphyrins has blossomed in recent years, driven in part by an appreciation that such systems have a role to play in exploring aromaticity effects, generating new cation complexing agents, and anion recognition. In the upcoming funding period, the focus will be on the synthesis of new systems via both rational and combinatorial methods, the use of oligopyrrolic macrocycles as frameworks for the generation of new organometallic and coordination complexes, and the creation of polymeric arrays. Applications of the resulting materials in molecular recognition will also be explored. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jonathan L. Sessler of the Department of Chemistry at The University of Texas at Austin. Professor Sessler's research efforts revolve around the development and study of new pyrrole-based macrocycles for use in medicine, supramolecular chemistry, coordination chemistry, waste remediation and heavy element research. The present project as formulated will provide new compounds and methods that will help drive various follow-up applications-related studies associated with drug development, nonlinear optics, materials research, waste remediation, and global sustainability.