Expanded Porphyrins and Other Synthetic Polypyrrole Macrocycles

该项目将继续致力于推进扩展卟啉和相关大环的化学研究。虽然与天然存在的类似物（如卟啉）相比，对扩展卟啉的研究远远不够，但近年来，扩展卟啉的化学研究蓬勃发展，部分原因是人们认识到这种系统在探索芳香性效应、产生新的阳离子络合剂和阴离子识别方面发挥着重要作用。在即将到来的资助期内，重点将放在通过合理和组合方法合成新系统，使用低聚吡啶大环作为框架，生成新的有机金属和配位配合物，以及创建聚合物阵列。本文还将探讨所得材料在分子识别方面的应用。有了这个奖项，有机和大分子化学项目支持了德克萨斯大学奥斯汀分校化学系的乔纳森·l·塞斯勒教授的研究。Sessler教授的研究工作主要围绕开发和研究新的吡咯基大环，用于医学、超分子化学、配位化学、废物修复和重元素研究。目前制定的项目将提供新的化合物和方法，这将有助于推动与药物开发、非线性光学、材料研究、废物修复和全球可持续性相关的各种后续应用相关研究。

This project will continue work devoted to advancing the chemistry of expanded porphyrins and related macrocycles. While far less well studied than their naturally occurring analogues (e.g., porphyrins), the chemistry of expanded porphyrins has blossomed in recent years, driven in part by an appreciation that such systems have a role to play in exploring aromaticity effects, generating new cation complexing agents, and anion recognition. In the upcoming funding period, the focus will be on the synthesis of new systems via both rational and combinatorial methods, the use of oligopyrrolic macrocycles as frameworks for the generation of new organometallic and coordination complexes, and the creation of polymeric arrays. Applications of the resulting materials in molecular recognition will also be explored. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jonathan L. Sessler of the Department of Chemistry at The University of Texas at Austin. Professor Sessler's research efforts revolve around the development and study of new pyrrole-based macrocycles for use in medicine, supramolecular chemistry, coordination chemistry, waste remediation and heavy element research. The present project as formulated will provide new compounds and methods that will help drive various follow-up applications-related studies associated with drug development, nonlinear optics, materials research, waste remediation, and global sustainability.