Expanded Porphyrins and Other Synthetic Polypyrrole Macrocycles

该项目将继续致力于推进扩展卟啉和相关大环化合物的化学研究。 虽然远不如其天然存在的类似物（例如，卟啉），膨胀卟啉的化学近年来已经蓬勃发展，部分地是由于认识到这种体系在探索芳香性效应、产生新的阳离子络合剂和阴离子识别中起作用。 在即将到来的资助期间，重点将是通过合理和组合方法合成新系统，使用寡聚吡咯大环作为生成新的有机金属和配位络合物的框架，以及创建聚合物阵列。 所得材料在分子识别中的应用也将被探索。有了这个奖项，有机和高分子化学计划是支持教授乔纳森L。德克萨斯大学奥斯汀分校化学系的Sessler博士说。 Sessler教授的研究工作围绕着开发和研究用于医学、超分子化学、配位化学、废物治理和重元素研究的新型吡咯基大环化合物。 目前制定的项目将提供新的化合物和方法，这将有助于推动与药物开发，非线性光学，材料研究，废物治理和全球可持续性相关的各种后续应用相关研究。

This project will continue work devoted to advancing the chemistry of expanded porphyrins and related macrocycles. While far less well studied than their naturally occurring analogues (e.g., porphyrins), the chemistry of expanded porphyrins has blossomed in recent years, driven in part by an appreciation that such systems have a role to play in exploring aromaticity effects, generating new cation complexing agents, and anion recognition. In the upcoming funding period, the focus will be on the synthesis of new systems via both rational and combinatorial methods, the use of oligopyrrolic macrocycles as frameworks for the generation of new organometallic and coordination complexes, and the creation of polymeric arrays. Applications of the resulting materials in molecular recognition will also be explored. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Jonathan L. Sessler of the Department of Chemistry at The University of Texas at Austin. Professor Sessler's research efforts revolve around the development and study of new pyrrole-based macrocycles for use in medicine, supramolecular chemistry, coordination chemistry, waste remediation and heavy element research. The present project as formulated will provide new compounds and methods that will help drive various follow-up applications-related studies associated with drug development, nonlinear optics, materials research, waste remediation, and global sustainability.