Expanded Porphyrins and Other Synthetic Heterocyclic Macrocycles

化学部的大分子、超分子和纳米化学计划支持德克萨斯大学奥斯汀分校的乔纳森·塞斯勒教授的一个项目，该项目涉及扩展的卟啉和相关杂环大环的化学。重点将放在新的、缺乏电子的大环上，与大多数扩展的卟啉相比，它们的电子是“颠倒的”。这些新的体系有望显示出有趣的分子识别特性，并作为构建更高阶超分子组装的基石。这将允许构建自组装的有机金属骨架、超分子有机骨架、螺纹伪轮烷和自组装电子转移系综等可能性。在本项目范围内制备的新分子和超分子材料预期对环境有反应，并对不止一种分析物作出反应。该计划很可能会产生具有广泛用途的新的化学实体，并由商业实体进行探索。这方面的工作有助于国家技术基础设施的发展。合成卟啉类似物领域的工作是高度跨学科的。它涉及有机合成、无机化学、光谱学、材料科学、催化和超分子化学等方面。它为年轻的研究人员提供了极好的培训，然后他们能够在包括学术界、工业界和政府在内的各种环境中工作。与其他研究小组的合作有助于工作的更广泛影响，并为参与该项目的学生提供教育机会。与海外合作者的合作研究经验非常有益，有助于在美国发展更强大的、具有科学和文化素养的人力资源基础。

The Macromolecular, Supramolecular and Nanochemistry Program of the Chemistry Division supports the research group of Professor Jonathan Sessler of the University of Texas at Austin on a project that involves the chemistry of expanded porphyrins and related heterocyclic macrocycles. Particular emphasis will be placed on new, electron deficient macrocycles whose electronics are "reversed" compared to those of most expanded porphyrins. These new systems are expected to display interesting molecular recognition properties and act as building blocks for the construction of higher order supramolecular assemblies. This will permit the construction of self-assembled organometallic frameworks, supramolecular organic frameworks, threaded pseudorotaxanes, and self-assembled electron transfer ensembles, among other possibilities. The new molecular and supramolecular materials prepared in the context of this project are expected to be environmentally responsive and to respond to more than one analyte. It is likely that new chemical entities with broad utility will emerge from this program and be explored by commercial entities. Work in this area contributes to the development of the nation's technological infrastructure. Work in the synthetic porphyrin analogue area is highly interdisciplinary. It involves aspects of organic synthesis, inorganic chemistry, spectroscopy, materials science, catalysis, and supramolecular chemistry. It provides excellent training for young researchers who are then able to work in a variety of settings, including academe, industry, and government. The collaborations with other research groups contribute to the broader impact of the work and provide educational opportunities for the students involved in the project. Collaborative research experience with overseas collaborators is highly beneficial and is contributing to the development of a stronger, scientifically and culturally literate human resource base in the U.S.