Ceramic Based Multi-Site Electrode for Electrochemical and Electrophysiological Recording

这些研究的主要目标是设计和开发基于陶瓷的多位点微传感器。目前，微传感器主要用于神经科学领域，用于研究神经化学物质和测量脑细胞的电特性。微传感器的优点是能够在小空间尺度（微米）上快速测量分子或电势，从而直接了解生物信号传导过程。此外，这种方法可以小型化，以便直接在现场使用。目前这种微传感器的设计价格昂贵，易碎，容易失效，应用范围有限。我们计划开发一种基于陶瓷微加工概念的新型传感器。由此产生的传感器可能制造成本更低，更坚固，更具惰性，并且能够同时测量化学物质和电势。这些微传感器在化学测量方面的潜在用途可能是广泛的。低成本的陶瓷微传感器有可能用于测量各种情况下的化学物质，例如大脑记录，用于控制发酵过程，用于确定药物纯度，用于确定水果和蔬菜的收获时间信息，并且它们可能具有各种额外的生物传感应用。这些微型传感器可能会对神经科学、农业、工业、政府和私人实验室以及公众产生全球性影响。

The major goal of these studies is to design and develop ceramic- based multisite microsensors. At the present time, microsensors are being used primarily in the area of neuroscience to study neurochemicals and to measure the electrical properties of brain cells. The advantages of microsensors are the abilities to rapidly (lsec) measure molecules or electrical potentials on small spatial scales (microns) to understand biological signaling processes directly. In addition, such methods can be miniaturized to be used directly in the field. Current designs of such microsensors have been expensive, fragile, subject to failure and limited in their scope of applications. We plan to develop a new type of sensor based on the concepts of the micromachining of ceramic. The resulting sensors may be cheaper to manufacture, stronger, and more inert, and capable of measuring chemicals and electrical potentials at the same time. The potential uses of these microsensors for chemical measurements may be extensive. It is possible that low cost ceramic-based microsensors can be used to measure chemicals in a variety of situations such as brain recordings, used to control fermentation processes, for determinations of the purity of drugs, for determining harvest time information regarding fruits and vegetables, and they will likely have a variety of additional biological sensing applications. These microsensors could have a global impact on neuroscience, agriculture, industry, government and private labs, and the general public.