Neurochemical Monitoring of Motor Regulatory Circuits in theRat Brain

大鼠大脑运动调节回路的神经化学监测

• 批准号: 9012745
• 负责人: Greg Gerhardt
• 金额: $ 3.19万
• 依托单位: University of Colorado at Denver
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-04-15 至 1991-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9012745&HistoricalAwards=false
• 关键词: Neurochemical; Monitoring; Motor; Regulatory; Circuits

The basal ganglia are a group of nuclei in the brain with major responsibility for causing movement of body parts. To date, neuroscientists have been able to collect anecdotal data from these motor nuclei by recording either electrical or chemical events from single cells within the basal ganglia. However, this approach does not tell us what ensembles of cells within the nuclei are doing at one instance to effect a movement. Thus, it is necessary to create and develop recording devices which will allow scientists to measure electrical and chemical events from multiple sites within a nucleus of cells if we are to fully understand how neural circuits operate to cause an arm to move for example. Dr. Greg Gerhardt is taking the initial steps in the development of solid-state microsensors that can be used to monitor the neurochemical substratum of motor regulation. He plans to develop and test biosensors to monitor chemical and electrical events in "real time" in the extracellular environment of striatal neurons. He proposes to develop multichannel silicon-based biosensors for the rapid determination of dopamine, glutamate, and acetylcholine activity in the basal ganglia of laboratory animals. This work is extremely important, being at the cutting edge of research which will allow us to understand the neurochemical mechanisms that underlie execution and control of brain motor circuits.

基底神经节是大脑中的一组核团， 造成身体部位移动的主要责任。 到 迄今为止，神经科学家已经能够收集轶事数据， 从这些运动核团中提取信息， 基底神经节内单细胞的化学反应。 然而，这种方法并没有告诉我们细胞的集合体是什么， 在一个情况下影响一个运动。 因此，有必要创建和开发记录设备 科学家们可以用它来测量电子和化学物质 如果我们想从细胞核内的多个位点收集信息， 完全理解神经回路是如何运作的， 举个例子。 格雷格·格哈特医生正在采取初步措施 在固态微传感器的开发中， 监测运动调节的神经化学基础。 他 计划开发和测试生物传感器，以监测化学和 细胞外环境中“真实的时间”的电事件 纹状体神经元。 他建议发展多渠道 用于快速测定多巴胺的硅基生物传感器， 谷氨酸和乙酰胆碱的活动在基底神经节的 实验室动物 这项工作非常重要，在 前沿的研究可以让我们了解 执行和控制的神经化学机制 大脑运动回路的一部分