NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1997

Paul D. Rawson本行动为1997年NSF/Alfred P. Sloan分子进化博士后研究奖学金提供资金。这些奖学金支持涉及生物进化变化和适应框架内分子水平生物模式和过程的理论、比较、计算和/或实验分析的研究。这些研究还包括利用分子数据来解决更广泛的进化问题。每个奖学金支持在赞助实验室进行的研究和培训计划。这项研究和培训计划的题目是“海洋桡足动物细胞核和线粒体细胞色素C氧化酶基因的共同进化”。海洋桡足动物加利福尼亚虎足被用来确定细胞色素C氧化酶基因共同进化的程度。细胞色素C氧化酶（Cytochrome C oxidase， CO）是细胞呼吸的关键酶，由核基因组和线粒体基因组中基因编码的亚基组成。序列变异被用来确定这些基因在遗传上不同的虎爪鼠种群中的共同进化。此外，还在确定一个种群的核基因是否能调节另一个种群的线粒体基因的表达，并影响它们在全酶中的组装。

Abstract DBI 9750052 Paul D. Rawson This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1997. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled "Coevolution of nuclear and mitochrondrial cytochrome C oxidase genes in a marine copepod." The marine copepod Tigriopus californicus is being used to determine the degree to which cytochrome C oxidase genes are coevolving. Cytochrome C oxidase (CO) is a key enzyme of cellular respiration and is composed of subunits encoded by genes in both the nuclear and mitochrondrial genomes. Sequence variations are being used to determine the coevolution of these genes in genetically divergent Tigriopus populations. Also, it is being determined if nuclear genes from one population can regulate the expression of mitochrondrial genes from another population and affect their assembly into the holoenzyme.