NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1998

DBI-9803909 Lisa Borghesi这一行动为美国国家科学基金会/阿尔弗雷德·P·斯隆1998年分子进化博士后研究奖学金提供了资金。这些奖学金支持在有机体进化变化和适应的框架内，在分子水平上对生物模式和过程进行理论、比较、计算和/或实验分析的研究。这些研究还包括使用分子数据来解决更广泛的进化问题。每个研究金资助一项研究和培训计划，该计划将在一个赞助实验室进行。该奖学金的研究和培训计划名为无脊椎动物脊索动物Botryllus schlosseri中自我/非自我识别的分子进化。本项目的目的是研究影响白僵菌自我/非自我识别(异体识别)的分子决定因素。同种异体识别系统在无脊椎动物、脊椎动物和植物中具有不同的功能，但同种异体识别基因座普遍具有非常高的多态水平。因此，对Botryllus中同种异体识别特异性的分子遗传学基础的分析可以阐明在许多群体中控制个体进化的一般原理。

Abstract DBI-9803909 Lisa Borghesi This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1998. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled molecular evolution of self/non-self recognition in the invertebrate chordate Botryllus schlosseri. This project aims to characterize the molecular determinants that mediate self/non-self recognition (allorecognition) in Botryllus schlosseri. Allorecognition systems serve disparate functions in invertebrates, vertebrates and plants, but allorecognition loci are universally marked by extraordinary levels of polymorphism. Analysis of the molecular genetic basis of allorecognition specificity, in Botryllus may therefore illustrate general principles governing the evolution of individuality in many groups.