NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1998

Lisa Borghesi为1998年NSF/Alfred P. Sloan分子进化博士后研究奖学金提供资金。这些奖学金支持涉及生物进化变化和适应框架内分子水平生物模式和过程的理论、比较、计算和/或实验分析的研究。这些研究还包括利用分子数据来解决更广泛的进化问题。每个奖学金支持在赞助实验室进行的研究和培训计划。该奖学金的研究和培训计划题为“无脊椎脊索动物Botryllus schlosseri自我/非自我识别的分子进化”。本项目的目的是表征的分子决定因素介导的自我/非自我识别（异体识别）的Botryllus schlosseri。同种异体识别系统在无脊椎动物、脊椎动物和植物中具有不同的功能，但同种异体识别位点普遍具有非凡的多态性水平。因此，对Botryllus中同种异体识别特异性的分子遗传基础的分析可能说明许多群体中个体进化的一般原则。

Abstract DBI-9803909 Lisa Borghesi This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1998. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled molecular evolution of self/non-self recognition in the invertebrate chordate Botryllus schlosseri. This project aims to characterize the molecular determinants that mediate self/non-self recognition (allorecognition) in Botryllus schlosseri. Allorecognition systems serve disparate functions in invertebrates, vertebrates and plants, but allorecognition loci are universally marked by extraordinary levels of polymorphism. Analysis of the molecular genetic basis of allorecognition specificity, in Botryllus may therefore illustrate general principles governing the evolution of individuality in many groups.