Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

这项研究包括光化学反应和过渡金属催化的环化反应，包括烯烃-乙烯基环丙烷、烯烃-乙烯基环丙烷、烯-乙烯基环丙烷、二烯基环丙烷(52)环加成反应和烯烃-乙烯基环丁酮(62)环加成反应。重点是发展对金属催化反应的基本了解，包括范围、选择性、速率和机理。通过这个续展奖项，有机化学和高分子化学项目为斯坦福大学化学系的Paul A.Wender博士的研究提供了持续的支持。这项研究涉及开发合成方法来制备含有环和不对称碳中心的有机化合物，在医学和生物学方面具有潜在的用途。这项工作将为研究生和博士后研究员提供有价值的有机合成、结构和机理方面的培训。

The research proposed involved continuing studies of photochemical and transition metal catalyzed cyclization reactions, including alkyne-vinylcyclopropane, alkene-vinylcyclopropane, allene-vinylcyclopropane, dienylcyclopropane (5+2) cycloadditions and alkene-vinylcyclobutanone (6+2) cycloadditions. Emphasis will be placed on developing a fundamental understanding of the metal catalyzed reactions, including scope, selectivities, rates, and mechanisms. With this renewal award, the Organic and Macromolecular Chemistry Program provides continuing support for the research of Dr. Paul A. Wender of the Department of Chemistry at Stanford University. The research involves the development of synthetic methods for preparing organic compounds containing rings and asymmetric carbon centers, with potential uses in medicine and biology. The work will provide valuable training to graduate students and post-doctoral fellows in organic synthesis, structure, and mechanism.