Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

建议的研究涉及持续的光化学研究， 过渡金属催化的环化反应，包括 炔-乙烯基环丙烷，烯烃-乙烯基环丙烷， 联烯-乙烯基环丙烷、二烯基环丙烷（5+2）环加成和 烯烃-乙烯基环丁酮（6+2）环加成反应。 重点将 致力于发展对金属催化的 反应，包括范围，选择性，速率和机制。 与 这个更新奖，有机和高分子化学计划 为Paul A博士的研究提供持续的支持。温德 斯坦福大学化学系。 研究 涉及到有机合成方法的发展 含环和不对称碳中心的化合物， 在医学和生物学中的应用。 这项工作将提供宝贵的训练 有机合成的研究生和博士后研究员， 结构和机制。

The research proposed involved continuing studies of photochemical and transition metal catalyzed cyclization reactions, including alkyne-vinylcyclopropane, alkene-vinylcyclopropane, allene-vinylcyclopropane, dienylcyclopropane (5+2) cycloadditions and alkene-vinylcyclobutanone (6+2) cycloadditions. Emphasis will be placed on developing a fundamental understanding of the metal catalyzed reactions, including scope, selectivities, rates, and mechanisms. With this renewal award, the Organic and Macromolecular Chemistry Program provides continuing support for the research of Dr. Paul A. Wender of the Department of Chemistry at Stanford University. The research involves the development of synthetic methods for preparing organic compounds containing rings and asymmetric carbon centers, with potential uses in medicine and biology. The work will provide valuable training to graduate students and post-doctoral fellows in organic synthesis, structure, and mechanism.