Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

改进综合设计的方法：新退火方法的机理和综合研究

• 批准号: 9800445
• 负责人: Paul Wender
• 金额: $ 56.18万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9800445&HistoricalAwards=false
• 关键词: Approaches; Improved; Synthesis; Design; Mechanistic

The research proposed involved continuing studies of photochemical and transition metal catalyzed cyclization reactions, including alkyne-vinylcyclopropane, alkene-vinylcyclopropane, allene-vinylcyclopropane, dienylcyclopropane (5+2) cycloadditions and alkene-vinylcyclobutanone (6+2) cycloadditions. Emphasis will be placed on developing a fundamental understanding of the metal catalyzed reactions, including scope, selectivities, rates, and mechanisms. With this renewal award, the Organic and Macromolecular Chemistry Program provides continuing support for the research of Dr. Paul A. Wender of the Department of Chemistry at Stanford University. The research involves the development of synthetic methods for preparing organic compounds containing rings and asymmetric carbon centers, with potential uses in medicine and biology. The work will provide valuable training to graduate students and post-doctoral fellows in organic synthesis, structure, and mechanism.

提出的研究包括继续研究光化学和过渡金属催化的环化反应，包括炔-乙烯基环丙烷、烯-乙烯基环丙烷、烯-乙烯基环丙烷、二烯基环丙烷（5+2）环加成和烯-乙烯基环丁酮（6+2）环加成。重点将放在发展对金属催化反应的基本理解，包括范围，选择性，速率和机制。有了这个更新的奖项，有机和大分子化学项目为斯坦福大学化学系Paul A. Wender博士的研究提供了持续的支持。这项研究包括开发合成方法，以制备含有环和不对称碳中心的有机化合物，在医学和生物学上具有潜在的用途。这项工作将为有机合成、结构和机理方面的研究生和博士后提供有价值的培训。