Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

这项研究的重点将包括探索简单的未活化的乙烯基环丙烷的[5+2]环加成反应，重排反应中的取代基效应，以及乙烯基环丙烷的[5+1]环加成反应和不对称的[5+2]环加成反应。还将进行水中金属催化的环加成反应、[6+2]环加成反应以及[8+1]、[8+2]和[8+4]环加成反应的研究。将探索涉及环丁酮的[3+2]和[4+2]环加成反应，以及[4+2+1]、[5+2+1]和[5+2+1+1]等多组分环加成反应，并对系列环加成反应进行研究。总体目标是为合成复杂分子开发新的反应和策略。通过这个续展奖项，有机和高分子化学项目支持斯坦福大学化学系的保罗·A·温德博士的研究。温德教授将致力于从根本上开发有机合成的新反应、试剂和策略。特别强调催化反应，这些反应在没有催化剂的情况下是被禁止的或难以实现的。进一步的意义来自于过渡金属催化在开发环境可接受的合成方面的巨大潜力，这些合成产生的试剂衍生废物很少。该项目为预备专业人员提供了一个极好的培训计划，研究结果可能会对化学以外的领域产生强烈影响，如制药业。

The focus of this research will include the exploration of [5+2] cycloaddition of simple, unactivated vinylcyclopropanes, of substituent effects in the rearrangement and [5+1] cycloaddition of vinylcyclopropanes and of asymmetric [5+2] cycloadditions. Metal-catalyzed cycloadditions in water, studies on [6+2] cycloadditions, and studies on [8+1], [8+2] and [8+4] cycloadditions will also be carried out. Exploration of [3+2] and [4+2] cycloadditions involving cyclobutanones and of multicomponent cycloadditions such as [4+2+1], [5+2+1] and [5+2+1+1] cases will be carried out and serial cycloadditions will be studied as well. The overall goal is to develop new reactions and strategies for the synthesis of complex molecules. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Paul A. Wender of the Department of Chemistry at Stanford University. Professor Wender will focus his work on developing fundamentally new reactions, reagents and strategies for organic synthesis. A special emphasis is placed on catalyzed reactions that, in the absence of catalyst, are forbidden or hard to achieve. Further significance derives from the enormous potential of transition metal catalysis in the development of environmentally acceptable syntheses that provide little reagent-derived waste. The project provides an excellent training program for pre-professionals and the results of the research could have a strong impact in areas outside chemistry, such as the pharmaceutical industry.