Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

改进综合设计的方法：新退火方法的机理和综合研究

• 批准号: 0131944
• 负责人: Paul Wender
• 金额: $ 64万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2004-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0131944&HistoricalAwards=false
• 关键词: Approaches; Improved; Synthesis; Design; Mechanistic

The focus of this research will include the exploration of [5+2] cycloaddition of simple, unactivated vinylcyclopropanes, of substituent effects in the rearrangement and [5+1] cycloaddition of vinylcyclopropanes and of asymmetric [5+2] cycloadditions. Metal-catalyzed cycloadditions in water, studies on [6+2] cycloadditions, and studies on [8+1], [8+2] and [8+4] cycloadditions will also be carried out. Exploration of [3+2] and [4+2] cycloadditions involving cyclobutanones and of multicomponent cycloadditions such as [4+2+1], [5+2+1] and [5+2+1+1] cases will be carried out and serial cycloadditions will be studied as well. The overall goal is to develop new reactions and strategies for the synthesis of complex molecules. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Paul A. Wender of the Department of Chemistry at Stanford University. Professor Wender will focus his work on developing fundamentally new reactions, reagents and strategies for organic synthesis. A special emphasis is placed on catalyzed reactions that, in the absence of catalyst, are forbidden or hard to achieve. Further significance derives from the enormous potential of transition metal catalysis in the development of environmentally acceptable syntheses that provide little reagent-derived waste. The project provides an excellent training program for pre-professionals and the results of the research could have a strong impact in areas outside chemistry, such as the pharmaceutical industry.

本研究的重点将包括探索简单的，未活化的乙烯基环丙烷的[5+2]环加成，在重排和乙烯基环丙烷的[5+1]环加成和不对称的[5+2]环加成的取代基效应。 还将进行水中金属催化的环加成、[6+2]环加成的研究以及[8+1]、[8+2]和[8+4]环加成的研究。 对环丁酮的[3+2]和[4+2]环加成反应以及[4+2+1]、[5+2+1]和[5+2+1+1]等多组分环加成反应进行了探索，并对系列环加成反应进行了研究。 总体目标是开发新的反应和策略，用于合成复杂分子。有了这个更新奖，有机和高分子化学计划是支持博士保罗A。斯坦福大学化学系的温德说。 温德教授将专注于开发全新的反应，试剂和有机合成策略。 特别强调的是在没有催化剂的情况下，被禁止或难以实现的催化反应。 进一步的意义来自于过渡金属催化在开发环境可接受的合成中的巨大潜力，这些合成几乎不产生试剂衍生的废物。 该项目为预科专业人员提供了一个很好的培训计划，研究结果可能会对化学以外的领域产生重大影响，例如制药行业。