Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

改进综合设计的方法：新退火方法的机理和综合研究

• 批准号: 1265956
• 负责人: Paul Wender
• 金额: $ 72万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265956&HistoricalAwards=false
• 关键词: Approaches; Improved; Synthesis; Design; Mechanistic

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Paul A. Wender and co-workers of the Department of Chemistry at Stanford University will explore the development of new reactions, reagents and catalysts for organic synthesis. Studies will focus on new reagents for [5+2] cycloadditions and on a new family of reactivity relaying reagents for multicomponent [5+2]/[4+2] cycloadditions. Studies will also be directed at new strategies for carbon-carbon bond activation, a required step in a large class of cycloaddition reactions. Finally, studies will be directed at the development of the first transporter-catalyst conjugates for imaging and sensing in biological systems. This research is directed at the introduction of new reactions, catalysts and reagents for organic synthesis and thus at the introduction of new strategies for synthesizing molecules of interest for theoretical, medicinal, materials, imaging and energy research. New reactions, catalysts and reagents change how we think about bond construction, thereby providing options for improving step and time economy and providing greener if not ideal approaches to making molecules of scientific and societal value. Such advances provide the foundation for the pharmaceutical, agricultural, fine chemicals, materials science, environmental science, and energy industries and the fundamental tools for scientific research. The focus of this work on molecular processes also advances our basic knowledge of molecular structure and function, which in turn provides the foundation for the molecularization of science from molecular anthropology to molecular zoology. As evident from over 300 former coworkers trained in this program, many in leadership positions in academia and in industry, this research provides an exceptional training program for undergraduates, graduate students and post-doctoral fellows, including those from historically under-represented groups, and a source of inspiration and knowledge for others to use chemistry to address pressing and unsolved problems in medicine, materials, diagnostics and energy research.

在这个由化学部化学合成项目资助的项目中，斯坦福大学化学系的Paul A. Wender教授和他的同事将探索有机合成的新反应、试剂和催化剂的发展。研究将集中在[5+2]环加成的新试剂和多组分[5+2]/[4+2]环加成的新反应性继电器系列试剂上。研究还将针对碳-碳键激活的新策略，这是大型环加成反应的必要步骤。最后，研究将针对第一个用于生物系统成像和传感的转运-催化剂偶联物的开发。本研究旨在为有机合成引入新的反应、催化剂和试剂，从而为理论、医学、材料、成像和能源研究引入新的合成分子策略。新的反应、催化剂和试剂改变了我们对键构建的看法，从而为提高步骤和时间经济性提供了选择，并为制造具有科学和社会价值的分子提供了更环保的方法。这些进步为制药、农业、精细化工、材料科学、环境科学和能源工业提供了基础，并为科学研究提供了基本工具。这项工作对分子过程的关注也促进了我们对分子结构和功能的基本认识，这反过来为从分子人类学到分子动物学的科学分子化提供了基础。在这个项目中接受培训的300多名前同事中，许多人在学术界和工业界担任领导职务，这项研究为本科生、研究生和博士后提供了一个特殊的培训计划，包括那些历史上代表性不足的群体，并为其他人提供灵感和知识来源，以利用化学来解决医学、材料、诊断和能源研究中紧迫和未解决的问题。