Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

改进综合设计的方法：新退火方法的机理和综合研究

• 批准号: 0848280
• 负责人: Paul Wender
• 金额: $ 79.71万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848280&HistoricalAwards=false
• 关键词: Approaches; Improved; Synthesis; Design; Mechanistic

The focus of this project is to advance understanding of the mechanisms and selectivities of recently introduced reactions, on the investigation of new reactions, and on the use of new reactions to produce novel scaffolds, materials, ligands, and catalysts. The research will include studies on the regioselectivity of [5+2] cycloadditions, studies of new 5- and 3-carbon agents for new [5+2] and [3+2] cycloadditions, serial [5+2]/[4+2] cycloadditions and a new [5+2]/Nazarov process for one step syntheses of [5.3.0] systems, studies on [3+2] cycloadditions of vinylaziridines (VA), Lewis acid mediated [3+2] cycloadditions of VAs, metal catalyzed [2+2+2+2] cycloadditions to produce cyclooctatetraenes and the use of these to make new materials, ligands, and catalysts. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Paul Wender in the Department of Chemistry at Stanford University. Professor Wender's research seeks to create new ways of doing synthesis and to use that expertise to advance the frontiers of chemistry, biology, medicine and materials science. New reactions offer new ways to think about synthetic problems, new process options that could minimize or avoid environmentally problematic steps and process inefficiencies, and often new mechanisms and insights that add to our basic knowledge of bonding, structure, and reactivity. At its most fundamental level, synthesis provides the opportunity to create new compounds with functions that advance knowledge of chemistry and open opportunities for the preparation of materials of value to our society including probes, medicines, materials, fine chemicals, agricultural chemicals, and functional devices.

该项目的重点是促进对最近引入的反应的机制和选择性的理解，对新反应的研究，以及使用新反应来生产新的支架，材料，配体和催化剂。 研究内容包括[5+2]环加成反应的区域选择性、新的[5+2]和[3+2]环加成反应的新的5-和3-碳试剂、系列[5+2]/[4+2]环加成反应和一步合成[5.3.0]体系的新的[5+2]/Nazarov方法的研究、乙烯基氮杂环丙烷（VA）的[3+2]环加成反应的研究、刘易斯酸介导的VA的[3+2]环加成，金属催化的[2+2+2+2]环加成以产生环辛四烯，以及这些在制备新材料、配体和催化剂中的用途。 有了这个奖项，有机和高分子化学计划正在支持保罗·温德教授在化学系在斯坦福大学的研究。 温德教授的研究旨在创造新的合成方法，并利用这种专业知识来推进化学，生物学，医学和材料科学的前沿。新的反应提供了思考合成问题的新方法，新的工艺选择可以最大限度地减少或避免环境问题的步骤和工艺效率低下，并且通常是新的机制和见解，增加了我们对键合，结构和反应性的基本知识。 在最基本的层面上，合成提供了创造新化合物的机会，这些化合物具有促进化学知识的功能，并为制备对我们社会有价值的材料提供了机会，包括探针，药物，材料，精细化学品，农业化学品和功能性设备。