Approaches to Improved Synthesis Design: Mechanistic and Synthetic Studies on New Annelation Methods

改进综合设计的方法：新退火方法的机理和综合研究

• 批准号: 0450638
• 负责人: Paul Wender
• 金额: $ 91.71万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-12-01 至 2008-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0450638&HistoricalAwards=false
• 关键词: Approaches; Improved; Synthesis; Design; Mechanistic

The focus of this research is to advance understanding of the mechanisms and selectivities of recently introduced reactions, on the investigation of newly identified reactions, and on the identification of new reactions including intermolecular allenyl- and alkenyl-vinylcyclopropane (VCP) [5+2] cycloadditions; allenyl-VCP-CO [5+2+1] cycloadditions; asymmetric [5+2] cycloadditions; metathetical processes for the generation of VCPs and VCBs (vinylcyclobutanes); [4+2+1] cycloadditions of dienes, alkenes, and CO; allene-diene-CO [2+2+1] cycloadditions; 3-component reactions based on dienes and allenes; [6+1] reactions of allenylcyclobutanes; carbonylative allenyl ether transpositions; [5+1+2+1] cycloadditions; [3+2]/[5+1] reactions; and the use of 4-component cycloadducts as ligands for catalysis and molecular recognition.With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Paul A. Wender in the Department of Chemistry at Stanford University. Professor Wender will focus his work on the design or discovery and development of fundamentally new reactions, reagents, and strategies for organic synthesis. The continuing emphasis of the project is on the identification of new reactions as new reactions enable new synthetic strategies and better if not ideal syntheses (high yielding, step economical, resource effective, operationally simple and environmentally acceptable) of targets of theoretical, materials, or medicinal value. A special emphasis is placed on catalyzed reactions, especially processes that in the absence of catalyst are forbidden or difficult to achieve. The introduction of new reactions offers new ways to think about synthetic problems, new process options that could minimize or avoid environmentally problematic steps and process inefficiencies, and often new mechanisms and insights that add to our basic knowledge of bonding, structure, and reactivity. The project has broader impact by engaging in education from outreach to high school students through the training of postdoctoral participants. Scientific impact on the chemical, pharmaceutical and agricultural industries will also accrue

本研究的重点是促进对最近引入的反应的机理和选择性的理解，对新发现的反应的研究，以及对新反应的鉴定，包括分子间丙二烯基和烯基乙烯基环丙烷（VCP）[5+2]环加成，丙二烯基VCP-CO [5+2+1]环加成，不对称[5+2]环加成，用于生成VCP和VCB的复分解过程（乙烯基环丁烷）;二烯、烯烃和CO的[4+2+1]环加成;丙二烯-二烯-CO [2+2+1]环加成;基于二烯和丙二烯的3组分反应;丙二烯基环丁烷的[6+1]反应;羰基化丙二烯基醚易位;[5+1+2+1]环加成反应; [3+2]/[5+1]反应;以及使用四组分环加成物作为催化和分子识别的配体。有了这个更新奖，有机和大分子化学计划支持博士的研究和教育活动。温德在斯坦福大学化学系。 温德教授将专注于设计或发现和开发全新的反应，试剂和有机合成策略。该项目的持续重点是识别新反应，因为新反应可以实现新的合成策略，以及更好的（如果不是理想的）合成（高产率，步骤经济，资源有效，操作简单和环境可接受的）理论，材料或药用价值的目标。特别强调催化反应，特别是在没有催化剂的情况下被禁止或难以实现的过程。新反应的引入提供了思考合成问题的新方法，可以最大限度地减少或避免环境问题步骤和工艺效率低下的新工艺选择，以及通常增加我们对键合，结构和反应性的基本知识的新机制和见解。该项目具有更广泛的影响，通过培训博士后参与者，参与从外联到高中生的教育。科学对化学、制药和农业的影响也将增加