Implantible Multiple Unit Visual Prosthesis: Towards a Second and Third Generation

植入式多单元视觉假体：迈向第二代和第三代

• 批准号: 9808040
• 负责人: Wentai Liu
• 金额: $ 50.11万
• 依托单位: North Carolina State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9808040&HistoricalAwards=false
• 关键词: Implantible; Multiple; Unit; Visual; Prosthesis

9808040 Liu The PI proposes to complete the construction of a retinal prosthesis designed to provide artificial vision to people blind due to the degeneration of retinal rod and cones, experienced in diseases such as retinitis pigmentosa and age- related macular degeneration. The prosthesis is divided into two parts, one outside of the eye to acquire, code, and transmit an image, and the other inside the eye to receive and decode image data, and then apply the requested stimulation pattern to the retina. The system design must minimize power consumption and be biocompatible. The external portion consists of a special pair of glasses onto which is mounted a mini-camera, video-capture circuit, and power and video-data transmission circuit. Electrical power is transmitted wirelessly to the electronics in the eye using a two wire-coil arrangement similar to a transformer. Inside the eye, a chip has been designed to stimulate the retina in such a way as to form a 20x20 pixel image. This chip receives it's power and video-data wirelessly from a transmitter on the glasses. The improved version of this chip should be capable of sending operating-status back to the glasses for monitoring. Chip specifications are based on preliminary biological testing at Johns Hopkins. Biological testing of the prosthesis will take place at Johns Hopkins University, using dogs that are blind due to a genetic disorder that causes rod/cone loss similar to RP in humans. ***

9808040 Liu主要研究者建议完成视网膜假体的构建，旨在为因视网膜色素变性和年龄相关性黄斑变性等疾病导致视网膜杆和视锥变性而失明的人提供人工视觉。 假体分为两个部分，一个在眼睛外部以获取、编码和传输图像，另一个在眼睛内部以接收和解码图像数据，然后将所请求的刺激模式应用于视网膜。 系统设计必须最大限度地降低功耗并具有生物相容性。 外部部分由一副特殊的眼镜组成，眼镜上安装有微型摄像头、视频采集电路、电源和视频数据传输电路。 使用类似于Transformer的双线线圈布置将电力无线传输到眼睛中的电子设备。 在眼睛内部，设计了一个芯片来刺激视网膜，以形成20 x20像素的图像。 这个芯片从眼镜上的发射器无线接收能量和视频数据。 该芯片的改进版本应该能够将操作状态发送回眼镜进行监控。 芯片规格是基于约翰霍普金斯的初步生物测试。 假体的生物学测试将在约翰霍普金斯大学进行，使用的狗是盲目的，由于遗传疾病，导致杆/锥损失类似于RP在人类。 ***