Molecular Control of Ovule Development

胚珠发育的分子控制

• 批准号: 9808395
• 负责人: Charles Gasser
• 金额: $ 20.5万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 2001-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9808395&HistoricalAwards=false
• 关键词: Molecular; Control; Ovule; Development

The ovules of higher plants play a central role in plant reproduction. In addition, because ovules are the precursors to seeds, ovule development is a critical component of crop productivity. Ovule development includes processes which typify development in all multicellular organisms and can be used as a model for studying fundamental mechanisms regulating morphogenesis and tissue differentiation in all organisms. The PI has identified a set of genes regulating critical steps in ovule developmental through isolation ovule mutations isolated by positional cloning methods. These include HUELLENLOS (HLL) and SHORT INTEGUMENTS 2 (SIN2) - both of which are essential for formation or expansion of the integuments (the precursors of the seed coat), and TSO1 - which is necessary for normal coordination of directional expansion of integument cells. The isolated genes will serve as tools for analysis of patterns of gene expression and for formation of initial models of the biochemical mechanism regulating ovule development. Completion of the proposed research will significantly increase understanding of genetic and molecular control of plant reproductive development and of morphogenesis and histogenesis in general. The cloned genes will also enable further research on regulation and manipulation of these fundamental developmental processes.

高等植物的胚珠在植物生殖过程中起着重要作用。 此外，由于胚珠是种子的前体，胚珠发育是作物生产力的关键组成部分。 胚珠发育包括在所有多细胞生物体中典型发育的过程，并且可以用作研究调节所有生物体中的形态发生和组织分化的基本机制的模型。 PI通过定位克隆方法分离胚珠突变，确定了一组调控胚珠发育关键步骤的基因。 这些包括HUELLENLOS（HLL）和SHORT INTEGRAMENTS 2（SIN 2）-两者都是珠被（种皮的前体）形成或扩展所必需的，以及TSO 1-珠被细胞定向扩展的正常协调所必需的。 分离的基因将作为分析基因表达模式和形成调控胚珠发育的生化机制的初始模型的工具。 完成拟议的研究将显着增加植物生殖发育和形态发生和组织发生的遗传和分子控制的理解。 克隆的基因还将使进一步研究这些基本发育过程的调控和操纵成为可能。