Activation of C-F Bonds by Aryl Carbocations

本研究的重点是研究碳阳离子中间体作为亲电氟化物在溶液中的C-F键活化。将研究氟在碳原子之间移动且可逆和可光谱表征的体系，并制备含有(C-F-C)键的离子。我们还将研究碳正离子对氟氯烃和全氟碳化合物中C-F键的激活作用。通过这一奖项，有机和高分子化学项目正在支持约翰霍普金斯大学化学系的Thomas Lectka博士的研究。Lectka教授将专注于开发实现选择性C-F键激活的方法。该项目对更好地生产多氟和全氟碳氢化合物这一重要商业产品具有潜在影响。

The focus of this research is to study C-F bond activation in solution using carbocation intermediates as electrophilic fluoride abstractors. Systems wherein fluoride shifts between carbon atoms and are reversible and spectroscopically characterizable will be studied and ions containing (C-F-C) bonds will be prepared. The carbocation mediated activation of C-F bonds in chlorofluorocarbons and perfluorocarbons will also be examined. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thomas Lectka of the Department of Chemistry at Johns Hopkins University. Professor Lectka will focus his work on developing methods for achieving selective C-F bond activation. The project has potential impact for the better production of poly- and perfluorinated hydrocarbons, important commercial products.