Activation of C-F Bonds by Aryl Carbocations

芳基碳阳离子活化 C-F 键

• 批准号: 9809433
• 负责人: Thomas Lectka
• 金额: $ 25万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9809433&HistoricalAwards=false
• 关键词: Activation; Bonds; Aryl; Carbocations

The focus of this research is to study C-F bond activation in solution using carbocation intermediates as electrophilic fluoride abstractors. Systems wherein fluoride shifts between carbon atoms and are reversible and spectroscopically characterizable will be studied and ions containing (C-F-C) bonds will be prepared. The carbocation mediated activation of C-F bonds in chlorofluorocarbons and perfluorocarbons will also be examined. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Thomas Lectka of the Department of Chemistry at Johns Hopkins University. Professor Lectka will focus his work on developing methods for achieving selective C-F bond activation. The project has potential impact for the better production of poly- and perfluorinated hydrocarbons, important commercial products.

本研究的重点是利用碳正离子中间体作为亲电氟化物萃取剂，研究溶液中C-F键的活化。其中氟化物在碳原子之间转移，是可逆的和光谱表征的系统将被研究和离子含有（C-F-C）键将被制备。还将研究碳阳离子介导的氟氯化碳和全氟化碳中C-F键的活化。有了这个奖项，有机和大分子化学项目支持约翰霍普金斯大学化学系的Thomas Lectka博士的研究。Lectka教授将专注于开发实现选择性C-F键激活的方法。该项目对更好地生产重要的商业产品多氟烃和全氟烃具有潜在影响。