New Approaches to Site-Selective Fluorination

在这个由化学部化学合成项目资助的项目中，约翰霍普金斯大学的Thomas Lectka教授正在开发新的化学方法，重点是位点选择性氟化，以生产化学上有趣的产品，这些产品不易通过其他方法获得。在约翰霍普金斯大学，Lectka教授管理着一个主要由本科生组成的研究小组。此外，研究生是K-12教育推广计划和化学奥林匹克竞赛的参与者；在霍普金斯大学提供的另一个名为LEAD的项目中，两名研究生每周花两次时间指导巴尔的摩市中心的中学生学习科学和数学。总之，在可预见的未来，pi计划继续在教育代表性不足的少数群体（尤其是非洲裔美国人和西班牙裔本科生）方面保持良好的记录。操作简单，低催化剂负载（如适用），相互相容性，温和的条件和广泛的范围是基本目标。最近对氟化学的广泛兴趣主要源于氟化化合物作为药物的用途。市场上近四分之一的顶级药品含有氟，使合成氟化方法，特别是那些适合后期功能化的方法，成为药物化学家武器库中最有价值的弹头之一。

AbstractIn this project funded by the Chemical Synthesis program of the Chemistry Division, Professor Thomas Lectka of Johns Hopkins University is developing new chemical methods focused on site-selective fluorination to produce chemically interesting products not easily accessible by other means. At Johns Hopkins, Professor Lectka, supervises a research group that contains predominately undergraduates. In addition, graduate students are participants in the K-12 educational outreach program and also the Chemistry Olympiad; in a separate program offered by Hopkins called LEAD, two grad students spend time mentoring inner-city Baltimore middle school students twice a week in science and math. In summary, the P.I. plans to continue a track record of educating underrepresented minority groups (especially African-American and Hispanic undergraduates) for the foreseeable future.Operational simplicity, low catalyst loadings (where applicable), mutual compatibility, mild conditions, and broad scope are the fundamental goals. The recent, widespread interest in fluorine chemistry stems primarily from the utility of fluorinated compounds as pharmaceuticals. Nearly one quarter of the top pharmaceuticals on the market contain fluorine, placing synthetic fluorination methods, particularly those amenable to late-stage functionalization, among the most valuable warheads in the arsenal of the medicinal chemist.