Polycomponent Catalysis in Organic Synthesis

有机合成中的多组分催化

• 批准号: 1152996
• 负责人: Thomas Lectka
• 金额: $ 40.5万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152996&HistoricalAwards=false
• 关键词: Polycomponent; Catalysis; Organic; Synthesis

In this project funded by the Chemical Synthesis (SYN) Program, Prof. Thomas Lectka of Johns Hopkins University develops new chemical methods that employ several independent catalysts working synergistically to produce chemically interesting and useful products not easily accessible in other ways. Besides theoretical interest, operational simplicity, low catalyst loadings, mutual compatibility, and broad scope will be fundamental goals as well. The foundation of the approach will be polycomponent catalysis (for example, a catalytic nucleophile in combination with an organometallic complex, a Lewis acid, and/or a phase transfer catalyst) that results in powerful methods for the synthesis of pharmaceutically relevant functionalized targets, including chiral fluorides, alkaloids, lactams and related compounds. A focus on new methods of fluorination is especially noted; fluorinated organic molecules provide fruitful and exciting new leads for drug discovery.This project would serve three main goals: 1) the development of complex yet highly worthwhile new chemical processes; 2) fundamentally new approaches to the synthesis of pharmaceutically relevant targets and other useful molecules; 3) and practical training in synthetic chemistry for graduate students (including members of underrepresented groups). Equally, exposure of numerous undergraduates to synthetic projects (especially at hospital-oriented Johns Hopkins) will help to prepare them for careers in health-related occupations.

在由化学合成（SYN）计划资助的该项目中，约翰·霍普金斯大学（Johns Hopkins University）的托马斯·莱克特卡（Thomas Lectka）教授开发了新的化学方法，这些方法采用了几种独立的催化剂协同工作，以生产化学有趣且有用的产品，不容易以其他方式访问。 除了理论上的兴趣外，操作简单，低催化剂负载，相互兼容性和广泛范围也将是基本目标。 该方法的基础将是多组分催化（例如，一种结合有机金属络合物，刘易斯酸和/或相转移催化剂的催化亲核试剂），从而为合成药物相关的功能化靶标提供了有力的方法，包括脊髓液化剂，包括脊髓液化液，藻类，Alkaloids，lactams，lactams，lactams，coledms and Rounds和Roundss and Rounds和Rounds。 特别注意对新的氟化方法的重点。氟化有机分子为药物发现提供了富有成果和令人兴奋的新铅。该项目将实现三个主要目标：1）发展复杂但高度值得的新化学过程； 2）从根本上讲，新的方法是合成药品相关靶标和其他有用分子的方法； 3）和研究生合成化学的实践培训（包括代表性不足的群体成员）。 同样，众多本科生接触合成项目（尤其是在医院的约翰·霍普金斯（Johns Hopkins））将有助于为与健康相关职业的职业做好准备。