Polycomponent Catalysis in Organic Synthesis

有机合成中的多组分催化

• 批准号: 1152996
• 负责人: Thomas Lectka
• 金额: $ 40.5万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152996&HistoricalAwards=false
• 关键词: Polycomponent; Catalysis; Organic; Synthesis

In this project funded by the Chemical Synthesis (SYN) Program, Prof. Thomas Lectka of Johns Hopkins University develops new chemical methods that employ several independent catalysts working synergistically to produce chemically interesting and useful products not easily accessible in other ways. Besides theoretical interest, operational simplicity, low catalyst loadings, mutual compatibility, and broad scope will be fundamental goals as well. The foundation of the approach will be polycomponent catalysis (for example, a catalytic nucleophile in combination with an organometallic complex, a Lewis acid, and/or a phase transfer catalyst) that results in powerful methods for the synthesis of pharmaceutically relevant functionalized targets, including chiral fluorides, alkaloids, lactams and related compounds. A focus on new methods of fluorination is especially noted; fluorinated organic molecules provide fruitful and exciting new leads for drug discovery.This project would serve three main goals: 1) the development of complex yet highly worthwhile new chemical processes; 2) fundamentally new approaches to the synthesis of pharmaceutically relevant targets and other useful molecules; 3) and practical training in synthetic chemistry for graduate students (including members of underrepresented groups). Equally, exposure of numerous undergraduates to synthetic projects (especially at hospital-oriented Johns Hopkins) will help to prepare them for careers in health-related occupations.

在这个由化学合成（SYN）计划资助的项目中，约翰霍普金斯大学的托马斯莱克特卡教授开发了新的化学方法，该方法采用几种独立的催化剂协同工作，以产生化学上有趣和有用的产品，这些产品不容易以其他方式获得。 除了理论上的兴趣，操作简单，低催化剂负载，相互兼容性和广泛的范围也将是基本目标。 该方法的基础将是多组分催化（例如，催化亲核试剂与有机金属络合物、刘易斯酸和/或相转移催化剂的组合），其导致用于合成药学相关的官能化靶标（包括手性氟化物、生物碱、内酰胺和相关化合物）的有力方法。 该项目的主要目标有三个：1）开发复杂但极具价值的新化学过程; 2）从根本上开发合成药物相关靶点和其他有用分子的新方法; 3）开发新的药物合成方法; 4）开发新的药物合成方法; 5）开发新的药物合成方法。3）和合成化学的研究生（包括代表性不足的群体的成员）的实践培训。 同样，许多本科生接触综合项目（特别是在以医院为导向的约翰霍普金斯）将有助于他们为健康相关职业做好准备。