Career: Catalytic, Enantioselective C-C Bond Forming Reactions of Imines

职业：亚胺的催化、对映选择性 C-C 键形成反应

• 批准号: 9874694
• 负责人: Thomas Lectka
• 金额: $ 27.2万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2003-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9874694&HistoricalAwards=false
• 关键词: Career; Catalytic; Enantioselective; Bond; Forming

Professor Leckta's multifaceted research efforts explore aspects of asymmetric transformations of imines. These include addition reactions of enol- and allylsilanes and ketene silyl acetals to imino esters catalyzed by chiral Lewis acids, asymmetric Staudinger and Baylis-Hillman reactions. Also, the development of novel catalysts based on diborane as a bifunctional Lewis acid and (bis)phosphine ligands is being pursued while incorporating computations to evaluate and possibly design useful catalytic species. Creating a bridge between the experimental and the theoretical is a hallmark of Professor Leckta'a teaching goals, with computational chemistry employed in the introductory as well as advanced aspects of his curriculum. Further, plans are being made to include high school teachers with one goal being to develop visual aids to pique the interest of high school students.With this CAREER award, the Synthetic Organic Program supports the research and teaching efforts of Dr. Thomas Leckta of Johns Hopkins University. Professor Leckta's research deals with new ways to make nitrogen-containing molecules called amines in such a way that the three- dimensional shape or chirality of the molecule is controlled. This is ever more important when designing the synthesis of biomolecules and drugs. Professor Leckta's teaching emphasizes the use of computers as a tool for predicting the outcome of chemical reactions before time is invested in actually trying the chemistry in the laboratory. An outreach program is being planned that will involve high school teachers and provide demonstrations of high-quality graphics and computations to high school students.

Leckta 教授的多方面研究工作探索了亚胺不对称转化的各个方面。 这些包括由手性路易斯酸催化的烯醇硅烷和烯丙基硅烷以及烯酮甲硅烷基缩醛与亚氨基酯的加成反应、不对称施陶丁格反应和贝利斯-希尔曼反应。 此外，人们正在开发基于乙硼烷作为双功能路易斯酸和（双）膦配体的新型催化剂，同时结合计算来评估和可能设计有用的催化物质。 在实验和理论之间架起一座桥梁是莱克塔教授教学目标的一个标志，他的课程的入门和高级部分都采用了计算化学。 此外，我们还计划将高中教师纳入其中，目标之一是开发视觉教具以激发高中生的兴趣。通过这一职业奖，合成有机项目支持约翰·霍普金斯大学托马斯·莱克塔博士的研究和教学工作。 莱克塔教授的研究涉及制造称为胺的含氮分子的新方法，其方式是控制分子的三维形状或手性。 在设计生物分子和药物的合成时，这一点变得更加重要。 莱克塔教授的教学强调在投入时间在实验室中实际尝试化学反应之前，使用计算机作为预测化学反应结果的工具。 正在计划一项外展计划，该计划将邀请高中教师参与，并向高中生提供高质量图形和计算的演示。