SGER: Design of a Biomolecular Distributed Operating Systems

SGER：生物分子分布式操作系统的设计

• 批准号: 9810000
• 负责人: John Reif
• 金额: $ 5万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9810000&HistoricalAwards=false
• 关键词: SGER; Design; Biomolecular; Distributed; Operating

Biomolecular molecular computation (BMC) uses biochemical methods to do computation at the molecular level. The goal of this research is to determine key required capabilities of a distributed operating system (BMC-OS) for BMC, including: (i) distributed flow of control,(ii) distributed message transmission and message handling, (iii) distribution and retrieval of data and files,(iv) locality optimizations, (v) data integrity assurance, an(vi)distributed I/O. The effort is focusing on a few key topics which have the most impact on the design of a BMC-OS :(a) Integrity Assurance, Decreased I/O and Error Resiliency--a combination of computer science and biochemical techniques are being used to do data fingerprinting and a very high fan-out data distribution method (using redundant coding) will be used to increase data error resiliency. (b) Models and Simulation Software for BMC-OS--Parameterized performance models are used to reflect the geometric and other constraints (e.g., solution and reagent concentration, spatial distribution of DNA strands, temperature, salinity, etc.) on the BMC-OS control, including the application of MEMs technology to automate BMC.

生物分子计算（BMC）是利用生物化学方法在分子水平上进行计算。本研究的目标是确定BMC的分布式操作系统（BMC-OS）所需的关键功能，包括：（i）分布式控制流，（ii）分布式消息传输和消息处理，（iii）数据和文件的分发和检索，（iv）局部优化，（v）数据完整性保证，（vi）分布式I/O。这项工作的重点是对BMC操作系统的设计影响最大的几个关键主题：（a）完整性保证、减少输入/输出和容错能力-目前正在使用计算机科学和生物化学技术相结合的方法来进行数据指纹识别，并将使用一种非常高的扇出数据分配方法（使用冗余编码）来增加数据容错能力。(b)BMC-OS的模型和仿真软件--参数化性能模型用于反映几何和其他约束（例如， 溶液和试剂浓度、DNA链的空间分布、温度、盐度等）关于BMC-OS控制，包括应用MEMs技术实现BMC自动化。