REU Site: A Cyberlinked Program in Computational Biomolecular Structure & Design

REU 网站：计算生物分子结构的网络链接程序

• 批准号: 1950697
• 负责人: Jeffrey Gray
• 金额: $ 48.54万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950697&HistoricalAwards=false
• 关键词: REU; Site; Cyberlinked; Program; Computational

This REU Site award to Johns Hopkins University, located in Baltimore, MD, will support the training of 12 students for 10 weeks during the summers of 2020 - 2022. Research is conducted in various labs of the Rosetta Commons (http://www.rosettacommons.org) located throughout the United States and abroad. It is anticipated that a total of 36 students, primarily from schools with limited research opportunities or are from an under-represented group, will be trained in the program. Students will learn how interdisciplinary, collaborative research is conducted, and all will present their work at scientific conferences. Upon completion of the REU program, students will gain an understanding of how to investigate biological problems from a structural perspective; experience computational molecular design; acquire a solid foundation in research methodologies in biochemistry, biophysics, computational biology, and molecular engineering; gain skills to collaborate with other scientists and engineers in other laboratories globally; and gain a deeper appreciation for the contributions that improved technology in these areas can make to society. Assessment of the program will be done thru the SALG URSSA tool. Students will be tracked after the program in order to determine their career paths.The research uses computational methods for prediction of the structure of biomolecules (which underlies their behavior and function) and the design of new biomolecules (important for materials, nanotechnology, and biotechnology). Example research projects include “Antibody engineering by deep learning”, “Design of protein-based small molecule sensor/actuators”, and “Modeling and designing RNA at high resolution”. The training program consists of a 1-week bootcamp where students learn computer coding and structural biology, 8 weeks of research in distributed labs (across the US and abroad), and a final week together at the annual Rosetta Conference. During the research period, students will complete an independent research project under the mentorship of a host lab, participate in weekly virtual journal clubs, prepare research proposals, and prepare a poster for presentation at the conference. All participants complete the Responsible Conduct of Research course. More information about the program is available at http://www.rosettacommons.org/intern, or by contacting the PI (Dr. Jeffrey J. Gray at [e-mail]) or the program administrator (Ms. Camille Mathis at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项授予位于马里兰州巴尔的摩的约翰·霍普金斯大学的REU Site奖将支持2020-2022年夏季为期10周的12名学生的培训。研究在位于美国和国外的Rosetta Commons(http://www.rosettacommons.org))的各个实验室进行。预计共有36名学生将在该方案中接受培训，这些学生主要来自研究机会有限的学校或来自代表性不足的群体。学生将学习如何进行跨学科的协作研究，所有人都将在科学会议上展示他们的工作。完成REU项目后，学生将了解如何从结构角度研究生物问题；体验计算分子设计；在生物化学、生物物理、计算生物学和分子工程方面获得坚实的研究方法论基础；获得与全球其他实验室的其他科学家和工程师合作的技能；并更深入地了解这些领域改进的技术可以为社会做出的贡献。将通过SALG Urssa工具对该方案进行评估。学生将在项目结束后被跟踪，以确定他们的职业道路。这项研究使用计算方法来预测生物分子的结构(这是他们行为和功能的基础)和新生物分子的设计(对材料、纳米技术和生物技术很重要)。范例研究项目包括“通过深度学习进行抗体工程”、“基于蛋白质的小分子传感器/致动器的设计”和“高分辨率的RNA建模和设计”。培训计划包括为期一周的训练营，学生们在那里学习计算机编码和结构生物学，在分散的实验室(在美国和国外)进行为期8周的研究，以及在年度罗塞塔会议上一起度过最后一周。在研究期间，学生将在主办实验室的指导下完成一个独立的研究项目，参加每周一次的虚拟期刊俱乐部，准备研究提案，并准备一张海报在会议上展示。所有学员完成《负责任的研究行为》课程。有关该计划的更多信息，请访问http://www.rosettacommons.org/intern，，或联系PI(杰弗里·J·格雷博士，电子邮件：[e-mail])或计划管理员(Camille Mathis女士，电子邮件：[e-mail])。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。