REU Site: A Cyberlinked Program in Computational Biomolecular Structure & Design

REU 网站：计算生物分子结构的网络链接程序

• 批准号: 1950697
• 负责人: Jeffrey Gray
• 金额: $ 48.54万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1950697&HistoricalAwards=false
• 关键词: REU; Site; Cyberlinked; Program; Computational

This REU Site award to Johns Hopkins University, located in Baltimore, MD, will support the training of 12 students for 10 weeks during the summers of 2020 - 2022. Research is conducted in various labs of the Rosetta Commons (http://www.rosettacommons.org) located throughout the United States and abroad. It is anticipated that a total of 36 students, primarily from schools with limited research opportunities or are from an under-represented group, will be trained in the program. Students will learn how interdisciplinary, collaborative research is conducted, and all will present their work at scientific conferences. Upon completion of the REU program, students will gain an understanding of how to investigate biological problems from a structural perspective; experience computational molecular design; acquire a solid foundation in research methodologies in biochemistry, biophysics, computational biology, and molecular engineering; gain skills to collaborate with other scientists and engineers in other laboratories globally; and gain a deeper appreciation for the contributions that improved technology in these areas can make to society. Assessment of the program will be done thru the SALG URSSA tool. Students will be tracked after the program in order to determine their career paths.The research uses computational methods for prediction of the structure of biomolecules (which underlies their behavior and function) and the design of new biomolecules (important for materials, nanotechnology, and biotechnology). Example research projects include “Antibody engineering by deep learning”, “Design of protein-based small molecule sensor/actuators”, and “Modeling and designing RNA at high resolution”. The training program consists of a 1-week bootcamp where students learn computer coding and structural biology, 8 weeks of research in distributed labs (across the US and abroad), and a final week together at the annual Rosetta Conference. During the research period, students will complete an independent research project under the mentorship of a host lab, participate in weekly virtual journal clubs, prepare research proposals, and prepare a poster for presentation at the conference. All participants complete the Responsible Conduct of Research course. More information about the program is available at http://www.rosettacommons.org/intern, or by contacting the PI (Dr. Jeffrey J. Gray at [e-mail]) or the program administrator (Ms. Camille Mathis at [e-mail]).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该REU网站授予位于马里兰州巴尔的摩的约翰霍普金斯大学，将在2020年至2022年的夏季为12名学生提供为期10周的培训。研究是在位于美国和国外的罗塞塔公地（http://www.rosettacommons.org）的各个实验室进行的。预计总共有36名学生将接受该项目的培训，这些学生主要来自研究机会有限的学校或来自代表性不足的群体。学生将学习如何进行跨学科的合作研究，并在科学会议上展示他们的工作。完成REU课程后，学生将了解如何从结构角度调查生物学问题；有计算分子设计经验；在生物化学、生物物理学、计算生物学和分子工程的研究方法方面有扎实的基础；获得与全球其他实验室的其他科学家和工程师合作的技能；并且更深刻地认识到这些领域的改进技术对社会的贡献。该计划的评估将通过SALG URSSA工具进行。课程结束后，将对学生进行跟踪，以确定他们的职业道路。该研究使用计算方法来预测生物分子的结构（这是它们的行为和功能的基础）和设计新的生物分子（对材料、纳米技术和生物技术很重要）。研究项目包括“基于深度学习的抗体工程”、“基于蛋白质的小分子传感器/致动器的设计”和“高分辨率RNA的建模和设计”。该培训计划包括为期1周的训练营，学生将学习计算机编码和结构生物学，在分布在美国和国外的实验室进行8周的研究，最后一周在年度罗塞塔会议上一起进行研究。在研究期间，学生将在主办实验室的指导下完成一个独立的研究项目，参加每周的虚拟期刊俱乐部，准备研究提案，并准备在会议上展示的海报。所有参与者完成负责任的研究行为课程。有关该计划的更多信息可访问http://www.rosettacommons.org/intern，或联系PI （Jeffrey J. Gray博士[e-mail]）或计划管理员（Camille Mathis女士[e-mail]）。该奖项反映了NSF的法定使命，并通过基金会的智力价值和更广泛的影响审查标准进行评估，认为值得支持。