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ITR: Self-Assembly of DNA Nano-Scale Structures for Computation

ITR：用于计算的 DNA 纳米级结构的自组装

基本信息

批准号：
0086015
负责人：
John Reif
金额：
$ 202万
依托单位：
Duke University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2000
资助国家：
美国
起止时间：
2000-09-01 至 2006-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0086015&HistoricalAwards=false
关键词：
ITR Self Assembly DNA Nano

项目摘要

EIA-0086015Reif, John H. Duke UniversityITR: Self-Assembly of DNA Nano-Scale Structures for ComputationThis project is a multi-institutional effort to investigate the use of DNA self-assembly to do massively parallel computations at the molecular scale. The main goal is to develop a proof-of-concept demonstration of the application of DNA self-assembly to various basic computational tasks, such as sequences of arithmetic and logical computations executed in massively parallel fashion, and the application of this method to computational problems such as integer factorization. The research involves testing of various input/output methods, development of novel DNA tiles with properties that facilitate the self-assembly and their visualization by imaging devices such as an atomic force microscope, and methods to minimize errors in self-assembly. Specifically, the experiments are being conducted to evaluate the speed and error rates of the various types of self-assembly reactions. In addition, experimental testing of massively parallel DNA self-assembly on particular problems, such as arithmetic and Boolean vector operations, is being performed. Some of the technological areas that could be impacted are the application of DNA Lattices as a substrate for surface chemistry and as a substrate for layout of nano-scale circuit components, the construction of 3D DNA lattices, and DNA motors and their application to DNA computations.

作者：Reif，John H.杜克大学ITR：DNA纳米级结构的自组装计算这个项目是一个多机构的努力，调查使用DNA自组装做大规模并行计算在分子尺度上。主要目标是开发一个DNA自组装应用于各种基本计算任务的概念验证演示，例如以大规模并行方式执行的算术和逻辑计算序列，以及这种方法在整数分解等计算问题中的应用。该研究涉及测试各种输入/输出方法，开发具有促进自组装特性的新型DNA瓦片，以及通过原子力显微镜等成像设备进行可视化，以及最大限度地减少自组装错误的方法。具体而言，正在进行实验以评估各种类型的自组装反应的速度和错误率。此外，目前正在就算术和布尔向量运算等特定问题进行大规模并行DNA自组装的实验测试。可能受到影响的一些技术领域是DNA晶格作为表面化学基底的应用，以及作为纳米级电路组件布局的基底，3D DNA晶格的构建和DNA马达及其在DNA计算中的应用。