The Molecular Design of Surface Active Polymers that Create Functional Surfaces

提出的研究计划包括功能性聚合物表面的基础研究，旨在设计用官能团修饰聚合物表面的新方法。采用的具体方法是分子设计和表面活性运载工具的合成，这些运载工具通过自组装过程将官能团携带到聚合物基质的表面。两个不同但综合的研究重点是：一个核心项目，重点是阐明末端功能和中心功能均聚物的平衡和动态表面特性，作为功能聚合物表面的模型系统；一个定向项目，旨在开发用于装饰生物材料表面的表面递送工具。综合核心研究包括模型聚合物的合成，功能聚合物表面的理论建模和实验表征，包括新表面的开发。分析技术。应用研究项目的重点是用细胞粘附配体和生长因子来装饰商业生物材料表面，这些生长因子可以在体内植入物表面诱导骨细胞的形成。提出的研究描述了新的方法，可以精确控制聚合物表面的化学功能，并将影响广泛的聚合物应用，从粘合剂到润滑剂和不粘或释放涂层。社会特别感兴趣的是需要创造新的生物材料表面，这些表面可以有效地与活组织结合。随着人类寿命的不断延长，对受损或缺失组织的合成替代品的需求日益迫切。新方法描述了合成下一代植入式生物材料，不仅是生物相容性，但旨在诱导直接的生物反应，如骨再生。这种问题工程的新方法有可能改善许多需要组织再生或修复的个体的生活质量。* * *

9810069 Koberstein The proposes research program constitutes a fundamental study of functional polymer surfaces directed toward the objective of devising new methods for decorating polymer surfaces with functional groups. The specific approach adopted is the molecular design and synthesis of surface active delivery vehicles that carry functional groups to the surface of a polymeric matrix by self assembly processes. Two distinct but integrated research thrusts are pursued: a core program that focuses on elucidating the equilibrium and dynamic surface properties of end-functional and center-functional homopolymers as model systems for functional polymer surfaces, and a directed program of studies aimed at developing surface delivery vehicles for decorating biomaterial surfaces. The comprehensive core research involves synthesis of model polymers,theoretical modeling and experimental characterization of functional polymer surfaces including development of a new surface.analysis technique. The applied research program is focused on decorating commercial biomaterial surfaces with cell adhesion ligands and growth factors that can induce the formation of bone cells at an implant surface placed in vivo. %%% The proposed research describes novel methods that allow precise controlof the chemical functionality at polymer surfaces and will impact a broad range of polymer applications that ranges from adhesives to lubricants and non-stick or release coatings. Of particular interest to society is the need to create new biomaterial surfaces that are designed to effectively interface with living tissues. As the human lifespan has continually increased there has emerged an urgent need for synthetic replacements for damaged or missing tissue. New methods are described to synthesize the next generation of implantable biomaterials that are not only biocompatible, but are designed to induce a direct biological response such as bone regeneration. This novel approach to ti ssue engineering has the potential to improve the quality of life of many individuals who are in need of tissueregeneration or repair. ***