The Molecular Design of Surface Active Polymers that Create Functional Surfaces

9810069科伯斯坦提出的研究计划构成了对功能聚合物表面的基础研究，旨在设计新的方法来装饰具有官能团的聚合物表面。所采用的具体方法是通过自组装过程将官能团携带到聚合物基质表面的表面活性递送载体的分子设计和合成。两个不同但综合的研究推进：一个核心计划，侧重于阐明末端官能化和中心官能化均聚物作为功能聚合物表面模型系统的平衡和动态表面性质，以及一个定向研究计划，旨在开发用于装饰生物材料表面的表面输送载体。全面的核心研究包括模型聚合物的合成、功能聚合物表面的理论建模和实验表征，包括开发一种新的表面分析技术。应用研究计划的重点是用细胞黏附配体和生长因子装饰商业生物材料表面，这些细胞黏附配体和生长因子可以在体内植入的植入表面诱导骨细胞的形成。%这项拟议的研究描述了能够精确控制聚合物表面化学官能度的新方法，并将影响从粘合剂到润滑剂和不粘或离型涂料的广泛聚合物应用。社会特别感兴趣的是需要创造新的生物材料表面，设计成有效地与活组织连接。随着人类寿命的不断延长，出现了对受损或缺失组织的合成替代物的迫切需求。描述了合成下一代可植入生物材料的新方法，这些材料不仅具有生物相容性，而且旨在诱导直接的生物反应，如骨再生。这种组织工程的新方法有可能改善许多需要组织再生或修复的人的生活质量。***

9810069 Koberstein The proposes research program constitutes a fundamental study of functional polymer surfaces directed toward the objective of devising new methods for decorating polymer surfaces with functional groups. The specific approach adopted is the molecular design and synthesis of surface active delivery vehicles that carry functional groups to the surface of a polymeric matrix by self assembly processes. Two distinct but integrated research thrusts are pursued: a core program that focuses on elucidating the equilibrium and dynamic surface properties of end-functional and center-functional homopolymers as model systems for functional polymer surfaces, and a directed program of studies aimed at developing surface delivery vehicles for decorating biomaterial surfaces. The comprehensive core research involves synthesis of model polymers,theoretical modeling and experimental characterization of functional polymer surfaces including development of a new surface.analysis technique. The applied research program is focused on decorating commercial biomaterial surfaces with cell adhesion ligands and growth factors that can induce the formation of bone cells at an implant surface placed in vivo. %%% The proposed research describes novel methods that allow precise controlof the chemical functionality at polymer surfaces and will impact a broad range of polymer applications that ranges from adhesives to lubricants and non-stick or release coatings. Of particular interest to society is the need to create new biomaterial surfaces that are designed to effectively interface with living tissues. As the human lifespan has continually increased there has emerged an urgent need for synthetic replacements for damaged or missing tissue. New methods are described to synthesize the next generation of implantable biomaterials that are not only biocompatible, but are designed to induce a direct biological response such as bone regeneration. This novel approach to ti ssue engineering has the potential to improve the quality of life of many individuals who are in need of tissueregeneration or repair. ***