The Molecular Design of Surface Active Polymers that Create Functional Surfaces

创建功能表面的表面活性聚合物的分子设计

• 批准号: 9810069
• 负责人: Jeffrey Koberstein
• 金额: $ 30万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9810069&HistoricalAwards=false
• 关键词: Molecular; Design; Surface; Active; Polymers

9810069 Koberstein The proposes research program constitutes a fundamental study of functional polymer surfaces directed toward the objective of devising new methods for decorating polymer surfaces with functional groups. The specific approach adopted is the molecular design and synthesis of surface active delivery vehicles that carry functional groups to the surface of a polymeric matrix by self assembly processes. Two distinct but integrated research thrusts are pursued: a core program that focuses on elucidating the equilibrium and dynamic surface properties of end-functional and center-functional homopolymers as model systems for functional polymer surfaces, and a directed program of studies aimed at developing surface delivery vehicles for decorating biomaterial surfaces. The comprehensive core research involves synthesis of model polymers,theoretical modeling and experimental characterization of functional polymer surfaces including development of a new surface.analysis technique. The applied research program is focused on decorating commercial biomaterial surfaces with cell adhesion ligands and growth factors that can induce the formation of bone cells at an implant surface placed in vivo. %%% The proposed research describes novel methods that allow precise controlof the chemical functionality at polymer surfaces and will impact a broad range of polymer applications that ranges from adhesives to lubricants and non-stick or release coatings. Of particular interest to society is the need to create new biomaterial surfaces that are designed to effectively interface with living tissues. As the human lifespan has continually increased there has emerged an urgent need for synthetic replacements for damaged or missing tissue. New methods are described to synthesize the next generation of implantable biomaterials that are not only biocompatible, but are designed to induce a direct biological response such as bone regeneration. This novel approach to ti ssue engineering has the potential to improve the quality of life of many individuals who are in need of tissueregeneration or repair. ***

小行星9810069 建议的研究计划构成了功能聚合物表面的基础研究，目的是设计新的方法来装饰聚合物表面的功能基团。 所采用的具体方法是通过自组装过程将官能团携带到聚合物基质表面的表面活性递送载体的分子设计和合成。两个不同的，但综合的研究重点是追求：一个核心计划，重点是阐明平衡和动态的表面性能的末端功能和中心功能的均聚物作为模型系统的功能聚合物表面，和一个定向的研究计划，旨在开发表面交付车辆装饰生物材料表面。 综合核心研究涉及模型聚合物的合成，功能聚合物表面的理论建模和实验表征，包括开发新的表面分析技术。 该应用研究计划的重点是用细胞粘附配体和生长因子装饰商业生物材料表面，这些细胞粘附配体和生长因子可以在体内植入物表面诱导骨细胞的形成。 该研究描述了一种新的方法，可以精确控制聚合物表面的化学功能，并将影响从粘合剂到润滑剂和不粘或防粘涂层的广泛聚合物应用。 社会特别感兴趣的是需要创造新的生物材料表面，其被设计为有效地与活组织接触。 随着人类寿命的不断延长，出现了对受损或缺失组织的合成替代品的迫切需求。 描述了新的方法来合成下一代的可植入生物材料，不仅是生物相容的，但旨在诱导直接的生物反应，如骨再生。 这种组织工程的新方法有可能改善许多需要组织再生或修复的人的生活质量。 ***