Bioactive Polymer Coatings

生物活性聚合物涂料

• 批准号: 0214363
• 负责人: Jeffrey Koberstein
• 金额: $ 35.4万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0214363&HistoricalAwards=false
• 关键词: Bioactive; Polymer; Coatings

The proposed program of research centers on the molecular design and fabrication of exciting new bioactive polymeric coatings that actively promote a desired biological response. The fundamental approach adopted for creating boinductive surface coatings is the delivery of precise doses of cell adhesion ligands, growth factors and other cell signaling motifs onto the surface of a polymeric biomaterial that is resistant to protein adsorption. Two novel polymer systems are proposed for fabricating bioinductive polymer surfaces: surface-active beta-functional block copolymers and functional hydrogels prepared by end-linking end-functional macromonomers. The synthesis of both complex materials systems takes advantage of the exceptional capability of the recently developed technique of atom transfer radical polymerization to prepare functional materials with high precision and efficiency. In addition to providing for precise control of surface composition, the proposed materials have been selected to allow for photo-patterning of bioactive functionality, an exciting tool that will be applied to create materials that can direct the spatial growth of cells into two- and three-dimensional patterns. Finally, a new method for applying these bioactive coatings to polymer surfaces is described that is based upon environmentally friendly supercritical fluids. The focus on supercritical coating technologies illustrates illustrates how considerations of the commercial applicability of the methods and materials selected have been factored into the overall research program. The success of this research program would have a positive influence on a broad range of biomaterial technologies relating to tissue regeneration and repair, medical implants and devices, and consumer products.

提出的研究计划以分子设计和制造令人兴奋的新型生物活性聚合物涂层为中心，积极促进所需的生物反应。用于创建双诱导表面涂层的基本方法是将精确剂量的细胞粘附配体、生长因子和其他细胞信号基体递送到抗蛋白质吸附的高分子生物材料表面。提出了两种用于制备生物感应聚合物表面的新型聚合物体系：表面活性β -功能嵌段共聚物和端连接端功能大单体制备的功能水凝胶。这两种复杂材料体系的合成利用了最近发展的原子转移自由基聚合技术的卓越能力，以高精度和高效率制备功能材料。除了提供对表面组成的精确控制外，所提出的材料已被选择用于生物活性功能的光图图化，这是一种令人兴奋的工具，将用于创建可以将细胞的空间生长引导成二维和三维模式的材料。最后，介绍了一种基于环境友好型超临界流体的聚合物表面生物活性涂层的新方法。对超临界涂层技术的关注说明了所选择的方法和材料的商业适用性是如何被考虑到整个研究计划中的。该研究项目的成功将对与组织再生和修复、医疗植入物和设备以及消费产品相关的广泛生物材料技术产生积极影响。