Upgrade of High-Pressure Liquid Chromatograph (HPLC) for Amino Acid Racemization (AAR) Research of Quaternary Geochronology and Paleoclimatology

9817645米勒这笔赠款提供了部分支持的成本获得高压液相色谱仪（HPLC）的氨基酸实验室在地质年代学研究中心，北极和阿尔卑斯山研究所，科罗拉多大学。 PI在野外和分析项目方面有着悠久的历史，这些项目将外消旋化作为解决第四纪古气候学问题的工具。 新的HPLC将利用反相HPLC的最新工程和方法学进展，并将允许从地质材料中常规分离大多数氨基酸立体异构体，样品量比以前少近两个数量级。 特别是，反相HPLC提供了测量D/L比率的优势，快速外消旋天冬氨酸，提供更大的年龄和古温度分辨率的环境变化在高纬度地区。 改进数据处理和数据处理将能够更有效地利用测量结果。 NSF正在进行的内部和合作研究计划旨在量化加拿大北极，俄罗斯北极，挪威北极以及澳大利亚和南极洲的气候变化。 该基金由地球科学仪器和设施计划（GENS/IF）和大气科学部的古气候计划（ATM/PC）共同提供支持。***

9817645MillerThis grant provides partial support for the costs of acquiring a High-Pressure Liquid Chromatograph (HPLC) for the Amino Acid Laboratory at the Center for Geochronologic Research, Institute of Arctic and Alpine Research, University of Colorado. The PI's have a long history of field and analytical programs that incorporate racemization as a tool to address issues in Quaternary paleoclimatology. The new HPLC will take advantage of recent engineering and methodological advances in reverse phase HPLC, and will allow routine separation of most amino acid stereoisomers from geological materials with nearly two orders of magnitude less sample than previously required. In particular, reverse phase HPLC offers the advantage of measuring D/L ratios for fast-racemizing aspartic acid, providing greater age and paleotemperature resolution for environmental change at high latitudes. Improved data processing and data handling will allow more efficient utilization of measurements. Ongoing NSF-sponsored in-house and collaborative research programs are targeted toward quantifying climate change in the Canadian Arctic, Russian Arctic, Norwegian Arctic, as well as in Australia and Antarctica. Support for this grant is shared between the Earth Sciences Instrumentation and Facilities Program (EAR/IF) and the Division of Atmospheric Sciences' Paleoclimate Program (ATM/PC). ***