Noncovalent Sources of Conformational Order in Small-and Medium-Sized Molecules

中小分子构象有序的非共价来源

• 批准号: 9820952
• 负责人: Samuel Gellman
• 金额: $ 33万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9820952&HistoricalAwards=false
• 关键词: Noncovalent; Sources; Conformational; Order; Small

This research project explores the factors responsible for the conformations of biomolecules with particular emphasis on arene-arene interactions in nucleic acids. A related area of inquiry involves the synthesis and characterization of "foldamers," which are structurally analogous to proteins and nucleic acids. It is hoped that a better understanding of the relationship between specific structural features and overall conformation will lead to advances in bioorganic and medicinal chemistry and materials science.With this award, the Organic and Macromolecular Chemistry Program supports the research of Professor Samuel H. Gellman of the University of Wisconsin at Madison. Professor Gellman seeks a better understanding of how specific structural features of biomolecules (such molecules as proteins, enzymes, and DNA) interact to provide their unique and essential shapes. Potential applications in the areas of medicinal chemistry and materials science could result from the insight provided by Professor Gellman's research team.

该研究项目探讨了影响生物分子构象的因素，特别强调了核酸中芳烃-芳烃的相互作用。 一个相关的研究领域涉及“折叠体”的合成和表征，折叠体在结构上类似于蛋白质和核酸。 希望对特定结构特征和整体构象之间关系的更好理解将导致生物有机和药物化学以及材料科学的进步。有了这个奖项，有机和高分子化学计划支持Samuel H.位于麦迪逊的威斯康星州大学的盖尔曼说。 Gellman教授寻求更好地了解生物分子（如蛋白质，酶和DNA等分子）的特定结构特征如何相互作用，以提供其独特和基本的形状。 在药物化学和材料科学领域的潜在应用可能来自Gellman教授的研究团队提供的见解。