CRC: Catalytic Manipulation of Amide-Based Molecules and Materials

CRC：酰胺基分子和材料的催化操作

• 批准号: 0404704
• 负责人: Samuel Gellman
• 金额: --
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0404704&HistoricalAwards=false
• 关键词: CRC; Catalytic; Manipulation; Amide; Based

This award supports the collaborative efforts of Samuel H. Gellman, Shannon S. Stahl, Qiang Cui and Arun Yethiraj at the University of Wisconsin-Madison together with Annelise E. Barron at Northwestern University. This team will develop and optimize metal-based amide exchange catalysts for the preparation of new amide-containing molecules and polymers. The carboxamide group is inert under many conditions, and this research therefore is focused on a fundamentally new challenge in terms of metal-mediated reactivity. The diverse ensemble of researchers will use experimental and theoretical approaches to explore both transamidation and amide metathesis as strategies for the generation of new classes of oligo- and polyamides, including biomimetic helical heteropolymers. This team will also examine template-controlled reactivity, in which non-covalent interactions between the polyamide and a template control the monomer sequence, and provide access to complex materials properties. The research will also probe the effect of monomer properties on the polymer self-assembly.Polyamides are a large and useful class of polymers that includes proteins, which are of pivotal importance in biological systems, and synthetic materials such as nylons and Kevlar. Proteins are very complex molecules that perform diverse functions; in contrast, synthetic polyamides have much simpler structures and simpler functions. This research aims to bridge the gap in structure and function between biological and synthetic polyamides and thereby generate entirely new materials of broad utility. Synthetic targets include antimicrobial agents, gene delivery vectors, and lung surfactants. Researchers trained through this program will have a broad-based experience in catalysis, organic synthesis, polymer synthesis, materials characterization, computation and biotechnology. This award is funded through the Collaborative Research in Chemistry Program (CRC) in the NSF Division of Chemistry.

该奖项支持塞缪尔H。Gellman，Shannon S.威斯康星大学麦迪逊分校的斯塔尔、崔强、阿伦·耶提拉以及安丽丝·E.西北大学的巴伦。该团队将开发和优化金属基酰胺交换催化剂，用于制备新的含酰胺分子和聚合物。羧酰胺基团在许多条件下是惰性的，因此这项研究的重点是在金属介导的反应性方面的一个全新的挑战。 不同的研究人员将使用实验和理论方法来探索转酰胺作用和酰胺复分解作用，作为生成新类别的寡聚物和聚酰胺的策略，包括仿生螺旋杂聚物。该团队还将研究模板控制的反应性，其中聚酰胺和模板之间的非共价相互作用控制单体序列，并提供对复杂材料特性的访问。 研究还将探索单体性质对聚合物自组装的影响。聚酰胺是一大类有用的聚合物，包括在生物系统中至关重要的蛋白质，以及尼龙和凯夫拉等合成材料。蛋白质是非常复杂的分子，执行不同的功能;相比之下，合成聚酰胺具有更简单的结构和更简单的功能。 这项研究旨在弥合生物和合成聚酰胺之间在结构和功能上的差距，从而产生具有广泛用途的全新材料。 合成靶点包括抗菌剂、基因递送载体和肺表面活性剂。通过该计划培训的研究人员将在催化，有机合成，聚合物合成，材料表征，计算和生物技术方面拥有广泛的经验。该奖项由NSF化学部的化学合作研究计划（CRC）资助。