Gamma-amino Acids and Gamma-peptide Foldamers

γ-氨基酸和γ-肽折叠体

• 批准号: 0848847
• 负责人: Samuel Gellman
• 金额: $ 65.6万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848847&HistoricalAwards=false
• 关键词: Gamma; amino; Acids; peptide; Foldamers

The Organic and Macromolecular Chemistry Program in the Chemistry Division at the National Science Foundation supports Professor Samuel Gellman at the University of Wisconsin, who will synthesize new, conformationally constrained -amino acids and derivatives, and evaluate the conformation of oligomers that contain these new subunits. The present focus of this research involves basic synthetic and structural chemistry. Specific goals of the proposed research are to develop efficient synthetic routes to new conformationally constrained peptide building blocks and to study the conformational behavior of oligomers that contain constrained residues with the aim of identifying new and stable foldamer secondary structures. Interest in the development of synthetic foldamers has been kindled by recognition of the many important and complex functions carried out by precisely folded oligomers, especially proteins, in biological systems. The proposed activities will expand the scope of previous landmark studies by pursuing an emerging family of foldamer compounds, the gamma peptides and their hybrids.Detailed understanding and research in synthetic foldamers will not only help to understand how biofoldamers fold and function but also enable the design of new materials with useful properties.The proposed foldamer research represents an excellent way to train young scholars for independent careers. Progress in this area demands applying a non-traditional combination of tools and concepts to areas as diverse as asymmetric organic synthesis and biophysical characterization of higher order molecular structure. Students who participate in this research, at the graduate or undergraduate levels, will emerge well-equipped to confront challenges in their independent careers. In addition, the proposed research offers an excellent basis for conveying to undergraduates in the classroom the essence, appeal, and significance of modern chemistry research. Specifically, this topic enables a lecturer to show how classical topics in organic reactivity and synthesis can be used to address new research challenges.

美国国家科学基金会化学部的有机和大分子化学项目支持威斯康星州大学的Samuel Gellman教授，他将合成新的构象受限的氨基酸和衍生物，并评估含有这些新亚基的低聚物的构象。目前的研究重点涉及基础合成和结构化学。拟议的研究的具体目标是开发有效的合成路线，以新的构象约束肽积木和研究的构象行为的寡聚体，含有约束的残基，目的是确定新的和稳定的折叠体二级结构。由于认识到生物系统中精确折叠的寡聚体，特别是蛋白质，具有许多重要而复杂的功能，人们对合成折叠体的开发产生了兴趣。拟议的活动将扩大以前的里程碑式的研究范围，通过追求一个新兴的家庭折叠分子化合物，伽玛肽及其杂交。详细了解和研究合成折叠分子不仅有助于了解生物折叠分子的折叠和功能，而且还可以设计新的材料与有用的属性。拟议的折叠分子研究是一个很好的方式来培养年轻学者的独立职业生涯。在这一领域的进展要求应用非传统的工具和概念的组合，以不同的领域，如不对称有机合成和生物物理表征的高阶分子结构。谁参加这项研究的学生，在研究生或本科水平，将出现装备精良，以面对他们的独立职业生涯的挑战。此外，拟议的研究提供了一个很好的基础，在课堂上传达给本科生的本质，吸引力和现代化学研究的意义。具体来说，本主题使讲师能够展示有机反应性和合成中的经典主题如何用于解决新的研究挑战。