Structure and Function in Foldamers with Heterogeneous Backbones

异质主链折叠体的结构和功能

• 批准号: 0551920
• 负责人: Samuel Gellman
• 金额: $ 49.3万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0551920&HistoricalAwards=false
• 关键词: Structure; Function; Foldamers; Heterogeneous; Backbones

With this award, the Organic and Macromolecular Chemistry Program supports the work of Professor Samuel H. Gellman, of the Chemistry Department at University of Wisconsin, Madison, WI. This research will involve investigations of structure and function in foldamers with heterogeneous backbones. Foldamers are oligomeric molecules that adopt well-defined conformations. These studies will increase our understanding of the ways in which noncovalent interactions within a molecule promote specific and stable molecular shapes. A key goal is to identify new foldamer backbones, and new design principles that will lead to novel unprecedented foldamers. Foldamer development provides an opportunity to probe relationships between local and global conformation-directing forces, thus offering fundamental insights on the origins of molecular shape preferences. In addition, the distinctive properties of foldamers provide new opportunities for the design of molecules with useful catalytic functions.The analysis of known foldamers and the development of new ones provides excellent training for young scientists, because such research requires mastery of multiple skills, including organic synthesis, conformational analysis via a variety of methods, and assessment and refinement of foldamer function. Foldamer research requires students to integrate these skills in unprecedented ways. The complexity of this research area involves collaboration with other laboratories, which enhances student training.

有了这个奖项，有机和高分子化学计划支持教授塞缪尔H。Gellman说，他是威斯康星州麦迪逊的威斯康星州大学化学系的教授。 这项研究将涉及结构和功能的调查，在折叠分子与异质骨干。 折叠体是采用明确定义的构象的低聚分子。 这些研究将增加我们对分子内非共价相互作用促进特定和稳定分子形状的方式的理解。一个关键的目标是确定新的折叠体骨架，和新的设计原则，这将导致新的前所未有的折叠体。 折叠分子的发展提供了一个机会，以探讨当地和全球的构象导向力之间的关系，从而提供了基本的见解的起源分子形状的偏好。此外，折叠体的独特性质为设计具有有用催化功能的分子提供了新的机会。对已知折叠体的分析和新折叠体的开发为年轻科学家提供了良好的培训，因为此类研究需要掌握多种技能，包括有机合成，通过各种方法进行构象分析，以及评估和改进折叠体功能。Foldamer研究要求学生以前所未有的方式整合这些技能。该研究领域的复杂性涉及与其他实验室的合作，这增强了学生的培训。